SynthesisJournal of cardiothoracic and vascular anesthesia2021
Right Ventricular Dysfunction in Patients With COVID-19: A Systematic Review and Meta-analysis.
Synthesis in Journal of cardiothoracic and vascular anesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 73 citations in OpenAlex.
- Impact of the transpulmonary pressure on right ventricle impairment incidence during acute respiratory distress syndrome: a pilot study in adults and children.Intensive care medicine experimental · 2024Article
- Correlation between worsening pneumonitis and right ventricular systolic function in critically ill patients with COVID-19.Echo research and practice · 2024Article
- Cardiopulmonary Complications after Pulmonary Embolism in COVID-19.International journal of molecular sciences · 2024Article
- Predicting mortality in severe Covid-19 Pneumonia: the role of right ventricular dysfunction.Journal of clinical monitoring and computing · 2024Observational
- Right heart echocardiography findings in hypoxic pneumonia patients during the COVID-19 pandemic in a South African population.European heart journal. Imaging methods and practice · 2023Article
- Echocardiography phenotypes of right ventricular involvement in COVID-19 ARDS patients and ICU mortality: post-hoc (exploratory) analysis of repeated data from the ECHO-COVID study.Intensive care medicine · 2023Observational
- High AST/ALT Ratio Is Associated with Cardiac Involvement in Acute COVID-19 Patients.Medicina (Kaunas, Lithuania) · 2023Article
- Point of care ultrasound findings in critically ill SARS-COV2 patients in an HIV endemic, resourced constrained setting.Heliyon · 2023Article
- Multimodality Cardiac Imaging in COVID.Circulation research · 2023Review
- Oxygenated right ventricular assist device as part of veno-venopulmonary extracorporeal membrane oxygenation to support the right ventricle and pulmonary vasculature.Journal of cardiothoracic surgery · 2023Article
- Dipeptidyl Amino-Peptidase 3 (DPP3) as an Early Marker of Severity in a Patient Population with Cardiogenic Shock.Diagnostics (Basel, Switzerland) · 2023Article
- Pulmonary hypertension at admission predicts ICU mortality in elderly critically ill with severe COVID-19 pneumonia: retrospective cohort study.Cardiovascular ultrasound · 2023Observational
- Pulmonary hypertension predicts higher mortality in patients admitted with severe COVID-19 infection.SAGE open medicine · 2023Article
- Article
- Expert consensus on the diagnosis and treatment of severe and critical coronavirus disease 2019 (COVID-19).Journal of intensive medicine · 2022Article
- COVID-19-Related ARDS: Key Mechanistic Features and Treatments.Journal of clinical medicine · 2022Review
- Cardiac impairments in postacute COVID-19 with sustained symptoms: A review of the literature and proof of concept.Physiological reports · 2022Review
- The Potential of Thyroid Hormone Therapy in Severe COVID-19: Rationale and Preliminary Evidence.International journal of environmental research and public health · 2022Review
- Incidence of acute myocardial injury and its association with left and right ventricular systolic dysfunction in critically ill COVID-19 patients.Annals of intensive care · 2022Article
- Coupling of right ventricular function to pulmonary circulation as an independent predictor for non invasive ventilation failure in SARSCoV 2-related acute respiratory distress syndrome.American heart journal plus : cardiology research and practice · 2022Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis systematic review and meta-analysis aimed to describe the features of right ventricular impairment and pulmonary hypertension in coronavirus disease (COVID-19) and assess their effect on mortality.
designThe authors carried out a systematic review and meta-analysis of observational studies.
settingThe authors performed a search through PubMed, the International Clinical Trials Registry Platform, and the Cochrane Library for studies reporting right ventricular dysfunction in patients with COVID-19 and outcomes.
participantsThe search yielded nine studies in which the appropriate data were available.
interventionsPooled odds ratios were calculated according to the random-effects model. MEASUREMENTS AND MAIN
resultsOverall, 1,450 patients were analyzed, and half of them were invasively ventilated. Primary outcome was mortality at the longest follow-up available. Mortality was 48.5% versus 24.7% in patients with or without right ventricular impairment (n = 7; OR = 3.10; 95% confidence interval [CI] 1.72-5.58; p = 0.0002), 56.3% versus 30.6% in patients with or without right ventricular dilatation (n = 6; OR = 2.43; 95% CI 1.41-4.18; p = 0.001), and 52.9% versus 14.8% in patients with or without pulmonary hypertension (n = 3; OR = 5.75; 95% CI 2.67-12.38; p < 0.001).
conclusionMortality in patients with COVID-19 requiring respiratory support and with a diagnosis of right ventricular dysfunction, dilatation, or pulmonary hypertension is high. Future studies should highlight the mechanisms of right ventricular derangement in COVID-19, and early detection of right ventricular impairment using ultrasound might be important to individualize therapies and improve outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.