ArticleScientific reports2021
Association of weight fluctuation with cardiovascular disease risk among initially obese adults.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Weight variability and cardiovascular outcomes: a systematic review and meta-analysis.Cardiovascular diabetology · 2023Pooled it
- Evaluation of leptin treatment on maintenance of body weight loss in diet-induced obese mice.Diabetes, obesity & metabolism · 2026Article
- Obesity accelerates cardiovascular ageing.European heart journal · 2025Review
- Deleterious Effects of Yoyo Dieting and Resistant Starch on Gastrointestinal Morphology.Nutrients · 2024Article
- Review
- BMI variability and cardiovascular outcomes within clinical trial and real-world environments in type 2 diabetes: an IMI2 SOPHIA study.Cardiovascular diabetology · 2024Observational
- The Impact of Weight Cycling on Health and Obesity.Metabolites · 2024Review
- The association of body mass index variability with cardiovascular disease and mortality: a mediation analysis of pooled cohorts.Frontiers in endocrinology · 2024Article
- Lnc-PXMP4-2-4 alleviates myocardial cell damage by activating the JAK2/STAT3 signaling pathway.Heliyon · 2023Article
- Obesity and Cardiovascular Risk: Systematic Intervention Is the Key for Prevention.Healthcare (Basel, Switzerland) · 2023Review
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association of fluctuations in body mass index with cardiovascular risk in long-term is not well understood. This study aimed to investigate cardiovascular outcomes of weight fluctuation. Total of 67,101 obese adults from the Korean National Health Insurance Service who received health examinations in three separate biennial periods were included. Participants were followed up from January 1, 2008 to the date of cardiovascular disease, death, or December 31, 2015, and categorized into 9 distinctive groups according to the BMI. Continuous weight gain showed an increased risk of overall cardiovascular disease (hazard ratio [HR], 2.36; P = 0.007), whereas weight loss after weight maintenance (HR, 0.91; P = 0.016) and weight maintenance after weight loss (HR, 0.91; P = 0.004) were ameliorative compared to the no weight change group. As for coronary heart disease, weight maintenance after weight gain was unfavorable (HR, 1.25; P = 0.004) while weight loss after weight maintenance (HR, 0.82; P < 0.001), weight cycling (HR, 0.83; P = 0.043), and weight maintenance after weight loss (HR, 0.88; P = 0.012) were beneficial. Weight maintenance after weight loss is beneficial for obese adults in terms of cardiovascular risks. In addition, weight loss is in part related to reduced risk of coronary heart disease despite weight cycling.
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