Evidence map›Paper›PMID 33983070›Full record

ArticleThe Journal of international medical research2021

Wedelolactone improves the renal injury induced by lipopolysaccharide in HK-2 cells by upregulation of protein tyrosine phosphatase non-receptor type 2.

Deyuan Zhi, Meng Zhang, Jin Lin, Pei Liu, Yajun Wang, Meili Duan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. PTPN2 in the Immunity and Tumor Immunotherapy: A Concise Review.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Deyuan ZhiDepartment of Critical Care Medicine, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China.
Meng ZhangDepartment of Critical Care Medicine, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China.
Jin LinDepartment of Critical Care Medicine, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China.
Pei LiuDepartment of Critical Care Medicine, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China.
Yajun WangDepartment of Critical Care Medicine, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China.
Meili DuanDepartment of Critical Care Medicine, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-1654-4606
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the effects of wedelolactone (WEL) on sepsis-induced renal injury in the human renal proximal tubular epithelial cell line HK-2.

methodsHK-2 cells were stimulated by 1 µg/ml lipopolysaccharide (LPS) to trigger renal injury

resultsCell viability was significantly increased in a dose-dependent manner by WEL in LPS-induced HK-2 cells. WEL also decreased the levels of four inflammatory cytokines and cell apoptosis in LPS-induced HK-2 cells. The level of PTPN2 was increased after WEL treatment. PTPN2 knockdown partly abolished the inhibitory effects of WEL on cell apoptosis, the levels of inflammatory cytokines and on p38 mitogen-activated protein kinase/nuclear factor-kappaB signalling in LPS-induced HK-2 cells.

conclusionWEL improved renal injury by suppressing inflammation and cell apoptosis through upregulating PTPN2 in HK-2 cells. PTPN2 might be used as a potential therapeutic target for LPS-induced sepsis.

Indexed as

LipopolysaccharidesApoptosisCell LineCoumarinsEpithelial CellsHumansKidneyNF-kappa BProtein Tyrosine PhosphatasesUp-RegulationCoumarinsLipopolysaccharidesNF-kappa BProtein Tyrosine Phosphataseswedelolactoneapoptosisinflammationprotein tyrosine phosphatase non-receptor type 2renal injuryWedelolactone

Identifiers

PMID33983070
PMCPMC8127797
OpenAlexW3161521782

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.