Evidence map›Paper›PMID 33984189›Full record

ArticlePharmacology research & perspectives2021

Seeking the exclusive binding region of phenylalkylamine derivatives on human T-type calcium channels via homology modeling and molecular dynamics simulation approach.

You Lu, Ming Li, Gi Young Lee, Na Zhao, Zhong Chen, Andrea Edwards, Kun Zhang

Open access · goldAbstract read
In one paragraph

Article in Pharmacology research & perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

You LuDepartment of Physics and Computer Science, Xavier University of Louisiana, New Orleans, LA, USA.ORCID 0000-0002-6815-6568
Ming LiDepartment of Physiology SL-39, Tulane University, New Orleans, LA, USA.
Gi Young LeeDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Na ZhaoKey Laboratory in Software Engineering of Yunnan Province, School of Software, Yunnan University, Kunming, China.
Zhong ChenDepartment of Physics and Computer Science, Xavier University of Louisiana, New Orleans, LA, USA.
Andrea EdwardsDepartment of Physics and Computer Science, Xavier University of Louisiana, New Orleans, LA, USA.
Kun ZhangDepartment of Physics and Computer Science, Xavier University of Louisiana, New Orleans, LA, USA.
Xavier University of Louisiana · USCornell University · USTulane University · USYunnan University · CN

Funding

Xavier RCMI Renewal Application-Research Infrastructure CoreU54MD007595 · NIMHD · XAVIER UNIVERSITY OF LOUISIANA · PI Guangdi Wang, Christopher Williams · 2019 to 2026
$41.9M
Xavier's RCMI Cancer Research ProgramG12MD007595 · NIMHD · XAVIER UNIVERSITY OF LOUISIANA · PI D'AMOUR, GENE, WANG, GUANGDI · 2012 to 2018
$15.7M
NIMHD NIH HHS U54 MD007595
6 · The paper itself

Abstract

Pharmaceutical features of phenylalkylamine derivatives (PAAs) binding to calcium channels have been studied extensively in the past decades. Only a few PAAs have the binding specificity on calcium channels, for example, NNC 55-0396. Here, we created the homology models of human Ca

Indexed as

Models, MolecularBenzimidazolesCalcium Channel BlockersCalcium Channels, T-TypeCyclopropanesHumansMibefradilNaphthalenesBenzimidazolesCalcium Channel BlockersCalcium Channels, T-TypeCyclopropanesMibefradilNaphthalenesNNC 55-0396homology modelingphenylalkylamineselective bindingT-type calcium channelsvirtual drug screening

Identifiers

PMID33984189
PMCPMC8118199
OpenAlexW3163204496

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.