Evidence map›Paper›PMID 33985492›Full record

SynthesisBMC oral health2021

Effect of photobiomodulation in secondary intention gingival wound healing-a systematic review and meta-analysis.

Pooya Ebrahimi, Mahdi Hadilou, Ferdos Naserneysari, Amirmohammad Dolatabadi, Rana Tarzemany, Nafiseh Vahed, Leila Nikniaz, Reza Fekrazad, Leila Gholami

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC oral health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Pooya EbrahimiStudent Research Committee, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Mahdi HadilouStudent Research Committee, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Ferdos NaserneysariStudent Research Committee, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Amirmohammad DolatabadiStudent Research Committee, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Rana TarzemanyDepartment of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
Nafiseh VahedResearch Center for Evidence-Based Medicine, A Joanna Briggs Institute Affiliated Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Leila NikniazTabriz Health Services Management Research Center, Faculty of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran.
Reza FekrazadDepartment of Periodontology, Dental Faculty, Laser Research Center in Medical Sciences, AJA University of Medical Sciences, Tehran, Iran.
Leila GholamiDepartment of Periodontics, Dental Research Center, School of Dentistry, Hamadan University of Medical Sciences, Shahid Fahmideh Blvd, 654178-38741, Hamadan, Iran. l.gholami@hotmail.com.
Tabriz University of Medical Sciences · IRAja University of Medical Sciences · IRHamedan University of Medical Sciences · IRUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhotobiomodulation is widely being used to improve the wound healing process in dentistry and a vast majority of studies have proven its benefits. But there are plenty of knowledge gaps according to the optimal laser characteristics which should be used to maximize the healing effects of lasers. The goal of this systematic review and meta-analysis was to determine the effect of photobiomodulation (PBM) as an adjunctive treatment to periodontal therapies to evaluate secondary intention gingival wound healing and post-operative pain.

methodsFive databases (PubMed, Embase, Scopus, ProQuest, and Web of Sciences) were searched up to November 30, 2020, for clinical trials that reported the result of the application of PBM on secondary gingival healing wounds and post-operative pain and discomfort after periodontal surgeries. Two independent reviewers selected the eligible studies and the outcomes of interest were extracted. The quality of eligible studies was assessed using the Cochrane Handbook for Systematic Reviews of Interventions.

resultsUltimately, twelve studies were included in this review. The application of PBM as an adjunct to periodontal surgeries resulted in a significant improvement in wound healing indices. The Landry wound healing index at the 7th post-operative day was significantly improved (SMD = 1.044 [95% CI 0.62-1.46]; p < 0.01) in PBM + surgery groups compared to the control groups. There was also a statistically significant increase in the complete wound epithelialization (RR = 3.23 [95% CI 1.66-6.31]; p < 0.01) at the 14th post-operative day compared to the control groups. The methods used to assess the post-operative pain were heterogeneous, and therefore the results were limited which made the meta-analysis for post-operative pain assessment not possible.

conclusionBased on the results of this review, PBM can be effectively used as a method to improve secondary intention wound healing. High-quality randomized clinical trials, however, are needed in the future to identify the optimal PBM irradiation parameters and the effect of PBM on post-operative pain.

Indexed as

IntentionWound HealingGingivaHumansPostoperative PainLow-level laser therapy (LLLT)Periodontal surgeryPhotobiomodulation (PBM)Secondary intention wound healing

Identifiers

PMID33985492
PMCPMC8120828
OpenAlexW3135224118

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.