ReviewJournal of the American College of Cardiology2021
Vascular Lesion-Specific Drug Delivery Systems: JACC State-of-the-Art Review.
Review in Journal of the American College of Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Pooled it
- mRNA medicine for cardiovascular disease.Nature cardiovascular research · 2026Review
- Predictors of target lesion revascularization after paclitaxel-coated balloon angioplasty forFrontiers in cardiovascular medicine · 2026Article
- DynamX Bioadaptor as an Emerging and Promising Innovation in Interventional Cardiology.Life (Basel, Switzerland) · 2025Review
- Analysis of the impact of nodular calcification on clinical outcome after drug-coated balloon angioplasty for femoropopliteal lesions.CVIR endovascular · 2025Article
- Restenosis patterns after percutaneous coronary intervention with drug-coated balloons for de novo coronary lesions.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Article
- PI3K Inhibitors as Potential Therapeutic Agents for the Treatment of COPD with Associated Atherosclerosis.Drugs · 2025Review
- Limus Devices for the Treatment of SFA: Latest Outcomes and Future Perspectives.Journal of clinical medicine · 2025Review
- Drug coated balloons in percutaneous coronary intervention: how can computational modelling help inform evolving clinical practice?Frontiers in medical technology · 2025Review
- Polygenic scores and antidepressant treatment outcomes in major depression: a critical integrative review.Neuroscience applied · 2025Article
- Predictive value of the quantitative flow ratio after pretreatment and drug-coated balloon therapy for functional stenosis of target vessels at the mid-term follow-up.Frontiers in cardiovascular medicine · 2025Article
- Optical coherence tomography findings after drug-coated balloon treatment forFrontiers in cardiovascular medicine · 2025Article
- Developing a Scanning Electron Microscopy Approach to Evaluate Paclitaxel Deposition From Drug Coated Balloons in a Human Cadaveric Peripheral Artery Disease Model.EJVES vascular forum · 2025Article
- Predictors of target lesion failure after percutaneous coronary intervention with a drug-coated balloon for de novo lesions.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024Article
- Programmed death of macrophages in atherosclerosis: mechanisms and therapeutic targets.Nature reviews. Cardiology · 2024Review
- Plaque heterogeneity and the spatial distributions of its components dictate drug-coated balloon therapy.Scientific reports · 2024Article
- Research progress of drug eluting balloon in arterial circulatory system.Frontiers in cardiovascular medicine · 2024Review
- Final 36-Month Outcomes from the Multicenter DynamX Study Evaluating a Novel Thin-Strut Novolimus-Eluting Coronary Bioadaptor System and Supporting Preclinical Data.Reviews in cardiovascular medicine · 2023Article
- Novel application of drug-coated balloons in coronary heart disease: A narrative review.Frontiers in cardiovascular medicine · 2023Review
- Three Technologies That Will Guide Revascularization of Chronic Coronary Syndrome Patients into the 21st Century: A Review.The International journal of angiology : official publication of the International College of Angiology, Inc · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Drug delivery is central to modern cardiovascular care, where drug-eluting stents, bioresorbable scaffolds, and drug-coated balloons all aim to restore perfusion while inhibiting exuberant healing. The promise and enthusiasm of these devices has in some cases exceeded demonstration of efficacy and even understanding of driving mechanisms. The authors review the means of drug delivery in each device, outlining how the technologies affect vascular behavior. They focus on how drug retention and response are governed by lesion morphology: lipid displacing drug-specific binding sites, calcium inhibiting diffusion, blocking thrombi or promoting luminal washout, and vascular healing steering hyperplastic developments. In this regard, the authors outline the fundamental impact of vascular structure on drug delivery and review the development of contemporary and future devices for coronary and peripheral intervention. They look toward a future where incorporating information on lesion distribution is central to therapeutic success and envision a transition toward lesion-specific treatment for improved interventional outcomes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.