ArticleScience (New York, N.Y.)2021
Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis.
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Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
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Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
- Systematic Engineering of Loss-of-Function Alleles in the Zebrafish Mitochondrial Proteome.bioRxiv : the preprint server for biology · 2026Article
- Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output.Cold Spring Harbor perspectives in biology · 2026Article
- The progress of mitochondrial function and transfer in stem cell regulation and therapy.Journal of physiology and biochemistry · 2026Review
- Histone arginine demethylase JMJD7 promotes bone formation through regulating α-Ketoglutarate metabolism.Cell death and differentiation · 2026Article
- Chemical Perturbations Impacting Histone Acetylation Govern Colorectal Cancer Differentiation.Gastroenterology · 2026Article
- Mtg16 NHR1 mutations cause defects in lymphopoiesis and the response to anemia.Experimental hematology · 2025Article
- DHODH modulates immune evasion of cancer cells via CDP-Choline dependent regulation of phospholipid metabolism and ferroptosis.Nature communications · 2025Article
- Are Mitochondria a Potential Target for Treating β-Thalassemia?Journal of clinical medicine · 2025Review
- Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer.Journal of translational medicine · 2025Article
- New insights into the mechanisms of red blood cell enucleation: From basics to clinical applications.EJHaem · 2024Review
- A glutamine metabolic switch supports erythropoiesis.Science (New York, N.Y.) · 2024Article
- Article
- Mitochondrial regulation in stem cells.Trends in cell biology · 2024Review
- Mitochondrial regulation of erythropoiesis in homeostasis and disease.British journal of haematology · 2024Review
- TRIM33 plays a critical role in regulating dendritic cell differentiation and homeostasis by modulating Irf8 and Bcl2l11 transcription.Cellular & molecular immunology · 2024Article
- Pseudouridine synthase 1 regulates erythropoiesis via transfer RNAs pseudouridylation and cytoplasmic translation.iScience · 2024Article
- Disruption of mitochondrial energy metabolism is a putative pathogenesis of Diamond-Blackfan anemia.iScience · 2024Article
- The role of CoQ10 in embryonic development.Journal of assisted reproduction and genetics · 2024Review
- Metabolic regulation of erythrocyte development and disorders.Experimental hematology · 2024Article
- Coenzyme Q biochemistry and biosynthesis.Trends in biochemical sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 8 institutions in 3 countries.
Marlies P RossmannDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA.ORCID https://orcid.org/0000-0003-2056-6792
Karen HoiDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA.
Victoria ChanDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA.ORCID https://orcid.org/0000-0002-4240-7138
Brian J AbrahamWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.ORCID https://orcid.org/0000-0001-8085-3027
Song YangStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
James MullahooBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID https://orcid.org/0000-0002-5469-4066
Malvina PapanastasiouBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID https://orcid.org/0000-0003-3378-6612
Ying WangDepartment of Biology, McGill University, Montréal, Québec H3A 1B1, Canada.
Ilaria EliaDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0003-0922-9429
Julie R PerlinStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0001-6694-9727
Elliott J HagedornStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0002-3824-3249
Sara HetzelDepartment of Genome Regulation, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
Raha WeigertDepartment of Genome Regulation, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.ORCID https://orcid.org/0000-0003-3698-8076
Sejal VyasDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Partha P NagBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Lucas B SullivanHuman Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.ORCID https://orcid.org/0000-0002-6745-8222
Curtis R WarrenBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Bilguujin DorjsurenDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA.ORCID https://orcid.org/0000-0002-8101-7482
Eugenia Custo GreigDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA.
Isaac AdattoDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA.ORCID https://orcid.org/0000-0002-9319-163X
Chad A CowanBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Stuart L SchreiberBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID https://orcid.org/0000-0003-1922-7558
Richard A YoungWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.ORCID https://orcid.org/0000-0001-8855-8647
Alexander MeissnerDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA.ORCID https://orcid.org/0000-0001-8646-7469
Marcia C HaigisDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0003-2530-2681
Siegfried HekimiDepartment of Biology, McGill University, Montréal, Québec H3A 1B1, Canada.ORCID https://orcid.org/0000-0002-3592-5711
Steven A CarrBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID https://orcid.org/0000-0002-7203-4299
Leonard I ZonDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA. leonard.zon@enders.tch.harvard.edu.ORCID https://orcid.org/0000-0003-0860-926X
Harvard University · USBroad Institute · USHarvard Stem Cell Institute · USBeth Israel Deaconess Medical Center · USMax Planck Institute for Molecular Genetics · DEMcGill University · CAWhitehead Institute for Biomedical Research · USFred Hutch Cancer Center · US
Funding
TRANSCRIPTION FACTOR GATA-1 IN TERMINAL ERYTHROID DEVELOPMENTP01HL032262 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI ORKIN, STUART H · 1985 to 2021
$38.9MTranscriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Jason Daniel Buenrostro · 2017 to 2026
$24.6MCustomized stem cells for clinical application in blood disordersR24DK092760 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI COLLINS, JAMES J, DALEY, GEORGE Q · 2011 to 2018
$10.7MThere and Back Again: Epigenetic Reinforcement of Cellular Signaling States - OverallU54HG008097 · NHGRI · BROAD INSTITUTE, INC. · PI JAFFE, JACOB DAVID · 2014 to 2019
$9.3MStem cells for therapeutics discovery in genetic blood disordersU01HL134812 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI DALEY, GEORGE Q, LIPTON, JEFFREY M · 2016 to 2022
$8.3MMolecular Circuits in the Hematopoietic Stem Cell NicheRC2DK120535 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI COLLINS, JAMES J, DALEY, GEORGE Q · 2020 to 2024
$8.2MSystems Biology of Bone Marrow Failure and MDS for Precision MedicineRC2DK122533 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI FIGUEROA, MARIA EUGENIA, FLEMING, MARK D · 2019 to 2023
$6.4MA Community Zebrafish Resource for Modeling GWAS BiologyR24OD017870 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM, MACRAE, CALUM A. · 2014 to 2021
$6.3MProject-002U54DK110805 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI ORKIN, STUART H, ZON, LEONARD IRA · 2016 to 2020
$5.9MEMBRYONIC HEMATOPOIESISR01HL048801 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI ZON, LEONARD IRA · 1992 to 2016
$5.7MStudies of Materials with Physiological PropertiesR35GM127045 · NIGMS · BROAD INSTITUTE, INC. · PI SCHREIBER, STUART L · 2018 to 2022
$3.2MTranscriptional response to signaling during hematopoiesisR01HL144780 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI ZON, LEONARD IRA · 2019 to 2022
$2.1MNCI NIH HHS R01 CA213062NHGRI NIH HHS U54 HG008097NHLBI NIH HHS P01 HL032262NHLBI NIH HHS P01 HL131477NHLBI NIH HHS R01 HL048801NHLBI NIH HHS R01 HL144780NHLBI NIH HHS U01 HL134812NIDDK NIH HHS K01 DK111790NIDDK NIH HHS R24 DK092760NIDDK NIH HHS RC2 DK120535NIDDK NIH HHS RC2 DK122533NIDDK NIH HHS U54 DK110805NIGMS NIH HHS R35 GM127045NIH HHS R24 OD017870
Abstract
Transcription and metabolism both influence cell function, but dedicated transcriptional control of metabolic pathways that regulate cell fate has rarely been defined. We discovered, using a chemical suppressor screen, that inhibition of the pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase (DHODH) rescues erythroid differentiation in bloodless zebrafish
Indexed as
ErythropoiesisTranscription, GeneticAnimalsCitric Acid CycleDihydroorotate DehydrogenaseDNA MethylationElectron TransportEmbryo, NonmammalianEnzyme InhibitorsGene Expression RegulationHistonesLeflunomideMetabolic Networks and PathwaysMethylationMitochondriaOxidoreductases Acting on CH-CH Group DonorsDihydroorotate DehydrogenaseEnzyme InhibitorsHistonesLeflunomideOxidoreductases Acting on CH-CH Group Donorstranscriptional intermediary factor 1gamma, zebrafishTranscription FactorsUbiquinoneZebrafish Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.