Evidence map›Paper›PMID 33986546›Full record

ArticleNature biotechnology2021

Quantitative profiling of pseudouridylation dynamics in native RNAs with nanopore sequencing.

Oguzhan Begik, Morghan C Lucas, Leszek P Pryszcz, Jose Miguel Ramirez, Rebeca Medina, Ivan Milenkovic, Sonia Cruciani, Huanle Liu, Helaine Graziele Santos Vieira, Aldema Sas-Chen and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 204 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
204citing papers in PubMed, 1 pooled it
20.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

204 citing papers in PubMed, 1 synthesis or guideline pooled it, 327 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Ψ-Atlas: An Integrated Atlas for Pseudouridine Epitranscriptome.Genomics, proteomics & bioinformatics · 2026
    Article
  6. The impact of psuedouridine modification on human tRNA.Biochemical Society transactions · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Integrating mass spectrometry with Nanopore direct RNA sequencing forbioRxiv : the preprint server for biology · 2026
    Article
  12. Review
  13. Review
  14. Article
  15. Pseudouridylation landscape across 42bioRxiv : the preprint server for biology · 2026
    Article
  16. Emerging roles of non-mNature plants · 2026
    Review
  17. Article
  18. Article
  19. Article
  20. Article

144 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Oguzhan Begik *Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Morghan C Lucas *Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID http://orcid.org/0000-0001-7654-9137
Leszek P PryszczCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Jose Miguel RamirezCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Rebeca MedinaCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Ivan MilenkovicCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Sonia CrucianiCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Huanle LiuCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID http://orcid.org/0000-0002-4910-3698
Helaine Graziele Santos VieiraCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Aldema Sas-ChenWeizmann Institute of Science, Rehovot, Israel.
John S MattickUNSW Sydney, Kensington, NSW, Australia.ORCID http://orcid.org/0000-0002-7680-7527
Schraga SchwartzWeizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0002-3671-9709
Eva Maria NovoaCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain. eva.novoa@crg.eu.ORCID http://orcid.org/0000-0002-9367-6311
Centre for Genomic Regulation · ESUniversitat Pompeu Fabra · ESWeizmann Institute of Science · ILGarvan Institute of Medical Research · AUInternational Institute of Molecular and Cell Biology · PLUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanopore RNA sequencing shows promise as a method for discriminating and identifying different RNA modifications in native RNA. Expanding on the ability of nanopore sequencing to detect N

Indexed as

AlgorithmsGene Expression ProfilingIntramolecular TransferasesMitochondriaNanopore SequencingPseudouridineRNARNA, FungalRNA, MessengerRNA Processing, Post-TranscriptionalRNA, RibosomalSaccharomyces cerevisiaeSequence Analysis, RNASoftwareStress, PhysiologicalIntramolecular TransferasesPseudouridineRNARNA, FungalRNA, MessengerRNA, RibosomaltRNA-pseudouridine synthase I

Identifiers

PMID33986546
OpenAlexW3162353597

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.