Evidence map›Paper›PMID 33993770›Full record

ArticleJournal of diabetes science and technology2021

Predictors of Change in Skin Intrinsic Fluorescence in Type 1 Diabetes: The Epidemiology of Diabetes Complications Study.

Erin L Tomaszewski, Trevor J Orchard, Marquis S Hawkins, Rebecca B N Conway, Jeanine M Buchanich, John Maynard, Thomas Songer, Tina Costacou

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes science and technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Erin L TomaszewskiGraduate School of Public Health Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-3995-3127
Trevor J OrchardGraduate School of Public Health Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Marquis S HawkinsGraduate School of Public Health Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Rebecca B N ConwayAmerican Academy of Epidemiology, Inc., Tyler, TX, USA.
Jeanine M BuchanichGraduate School of Public Health Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.
John MaynardMedical Device and Diagnostics Consultant, Atlanta, GA, USA.
Thomas SongerGraduate School of Public Health Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Tina CostacouGraduate School of Public Health Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
University of Pittsburgh · USAmerican Academy of Dermatology · US

Funding

Institutional Career Development CoreKL2TR001856 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, KRISTIN N, RUBIO, DORIS M · 2016 to 2025
$13.8M
EPIDEMIOLOGY OF DIABETIC COMPLICATIONS--PHASE IIR01DK034818 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COSTACOU, TINA · 1986 to 2019
$5.6M
NCATS NIH HHS KL2 TR001856NIDDK NIH HHS R01 DK034818
6 · The paper itself

Abstract

backgroundSkin intrinsic fluorescent (SIF) scores are indirect measures of advanced glycation end-products (AGEs). SIF scores are cross-sectionally associated with type 1 diabetes (T1D) complications such as increased albumin excretion rate (AER), coronary artery calcification (CAC) and neuropathy. We assessed predictors of SIF score change in those with T1D.

methodsData from the 30-year longitudinal Epidemiology of Diabetes Complications (EDC) study of childhood-onset T1D were used to assess AGEs measured with a SIF score produced by the SCOUT DS® device. SIF scores were assessed twice in 83 participants: between 2007-08 and again between 2010-14. Regression analyses were used to assess independent predictors of SIF score change.

resultsAt baseline, mean age was 47.9 ± 6.9 years, diabetes duration was 36.7 ± 6.4 years, and median glycosylated hemoglobin (HbA1c) was 7.1 (interquartile range: 6.5, 8.5). During a mean follow-up of 5.2 ± 0.9 years, mean change in SIF score was 2.9 ± 2.8 arbitrary units. In multivariable linear regression models, log HbA1c (

conclusionsIncreases in SIF score over 5 years were related to increased glycemic levels and decreased kidney function (eGFR). MDI and glomerular damage were related to a decreased SIF score. This is one of the first studies with repeated SIF assessments in T1D and provides unique, albeit preliminary, insight about these associations.

Indexed as

Diabetes ComplicationsDiabetes Mellitus, Type 1AdultFluorescenceGlycated HemoglobinGlycation End Products, AdvancedHumansMiddle AgedSkinGlycated HemoglobinGlycation End Products, Advancedadvanced glycation end-productscomplicationsEpidemiology of Diabetes Complications studyskin intrinsic fluorescencetype 1 diabetes

Identifiers

PMID33993770
PMCPMC8655295
OpenAlexW3160606587

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.