Evidence map›Paper›PMID 33995670›Full record

ArticleTheranostics2021

Apilimod alters TGFβ signaling pathway and prevents cardiac fibrotic remodeling.

Mathieu Cinato, Laurie Guitou, Amira Saidi, Andrei Timotin, Erwan Sperazza, Thibaut Duparc, Sergey N Zolov, Sai Srinivas Panapakkam Giridharan, Lois S Weisman, Laurent O Martinez and 4 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Development of a Second-Generation,Journal of medicinal chemistry · 2025
    Article
  4. Review
  5. Article
  6. Roles of PIKfyve in multiple cellular pathways.Current opinion in cell biology · 2022
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Mathieu CinatoINSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Laurie GuitouINSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Amira SaidiINSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Andrei TimotinINSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Erwan SperazzaINSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Thibaut DuparcINSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Sergey N ZolovLife Sciences Institute, University of Michigan, Ann Arbor, USA.
Sai Srinivas Panapakkam GiridharanLife Sciences Institute, University of Michigan, Ann Arbor, USA.
Lois S WeismanLife Sciences Institute, University of Michigan, Ann Arbor, USA.
Laurent O MartinezINSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Jerome RoncalliINSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Oksana KunduzovaINSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Helene TronchereINSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Frederic BoalINSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Inserm · FRInstitut des Maladies Métaboliques et Cardiovasculaires · FRUniversité Toulouse III - Paul Sabatier · FRUniversity of Michigan · USLouisiana State University System · USUniversité Fédérale de Toulouse Midi-Pyrénées · FR

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Phosphoinositide signaling: novel potential targets for Huntington diseaseR01NS099340 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEISMAN, LOIS S · 2017 to 2021
$2.7M
NIDDK NIH HHS P30 DK020572NINDS NIH HHS R01 NS099340
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCells, CulturedDrug Evaluation, PreclinicalFibroblastsFibrosisHeart FailureHEK293 CellsHeLa CellsHumansHydrazonesMaleMiceMice, Inbred C57BLMorpholinesMyocardiumPhosphatidylinositol 3-KinasesapilimodHydrazonesMorpholinesPhosphatidylinositol 3-KinasesPIKFYVE protein, humanPikfyve protein, mousePyrimidinesReceptor, Transforming Growth Factor-beta Type IITransforming Growth Factor betaApilimodfibrotic remodelingHeart failurePIKfyveTGFβ.

Identifiers

PMID33995670
PMCPMC8120213
OpenAlexW3159887036

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.