Evidence map›Paper›PMID 33997465›Full record

ArticleCurrent opinion in endocrine and metabolic research2021

The effects of plasticizers on the ovary.

Alison M Neff, Jodi A Flaws

Abstract read
In one paragraph

Article in Current opinion in endocrine and metabolic research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alison M NeffDepartment of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Jodi A FlawsDepartment of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Funding

Research Training Program in Toxicology and Environmental HealthT32ES007326 · NIEHS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Jodi A. Flaws · 2000 to 2026
$8.7M
Gender and sex differences in phthalate-induced toxicity in the reproductive systemR01ES032163 · NIEHS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BAGCHI, INDRANI C, FLAWS, JODI A. · 2020 to 2023
$2.2M
Phthalates and Ovarian ToxicityR01ES028661 · NIEHS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI FLAWS, JODI A. · 2018 to 2022
$1.8M
NIEHS NIH HHS R01 ES028661NIEHS NIH HHS R01 ES032163NIEHS NIH HHS T32 ES007326
6 · The paper itself

Abstract

Endocrine disrupting chemicals pose a threat to health and reproduction. Plasticizers such as phthalates and bisphenols are particularly problematic because they are present in many consumer products and exposure can begin in utero and continue throughout the lifetime of the individual. Evidence suggests that these chemicals can have ancestral and transgenerational effects, making them a huge public health concern for the reproductive health of current and future generations. Studies performed in rodents or using rodent- or human-derived tissues have been critical for understanding the toxic effects of plasticizers on the ovary and their mechanisms of action. This review addresses current in vitro and rodent-based in vivo studies investigating the effects of bisphenols and phthalates on ovarian health, female reproduction, and correlations between human exposure and reproductive pathologies.

Indexed as

endocrine disruptionfolliculogenesisOvaryplasticizersteroidogenesis

Identifiers

PMID33997465
PMCPMC8117085

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.