Evidence map›Paper›PMID 33997754›Full record

ArticleMetabolism open2021

Toyin Mohammed Salman, Mayowa Adewale Iyanda, Abdul-Musawwir Alli-Oluwafuyi, Sheu Oluwadare Sulaiman, Abdullateef Isiaka Alagbonsi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolism open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 4 countries.

Toyin Mohammed SalmanDepartment of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
Mayowa Adewale IyandaDepartment of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
Abdul-Musawwir Alli-OluwafuyiDepartment of Pharmacology and Therapeutics, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
Sheu Oluwadare SulaimanPhysiology Department, Kampala International University - Western Campus, Ishaka-Bushenyi, Uganda.
Abdullateef Isiaka AlagbonsiDepartment of Clinical Biology (Physiology), School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Huye Campus, Rwanda.
University of Ilorin · NGUniversidade Federal de Minas Gerais · BRUniversity of Rwanda · RW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

objectiveThis study determined the effect of ethyl acetate and n-hexane fractions of TO leaf extracts on some biochemical parameters in the glucose metabolic pathway to explain the possible fate of blood glucose following TO-induced hypoglycaemia.

methodsEighteen male Wistar rats (180-200 g) divided into control, n-hexane TO fraction- and ethyl acetate TO fraction-treated groups (n = 6/group) were used. The control animals received normal saline while the treated groups received TO at 100 mg/kg for seven days. After 24 h following the last dose, the animals were anaesthetised using ketamine; blood samples were collected and livers harvested to determine some biochemical parameters.

resultsEthyl acetate TO fraction significantly increased plasma insulin, liver glucokinase activity and plasma pyruvate concentration, but significantly decreased plasma glucose and liver glycogen, without significant changes in plasma lactate, glucose-6-phosphate, liver glucose-6-phosphatase and lactate dehydrogenase activities when compared with control. N-hexane TO fraction significantly reduced liver glucose-6-phosphatase activity and glycogen but significantly increased plasma pyruvate, without significant changes in plasma glucose, insulin, glucose-6-phosphate and lactate concentrations; and liver glucokinase and lactate dehydrogenase activities.

conclusionThe present study showed that insulin-mediated TO-induced hypoglycaemia resulted in the stimulation of glycolysis and pyruvate production via insulin-dependent and insulin-independent mechanisms.

Indexed as

ANOVA, Analysis of VarianceATP, Adenosine triphosphateEATO, Ethyl acetate TO fractionELISA, Enzyme-linked immunosorbent assayG6Pase, Glucose-6-phosphataseG6PD, Glucose-6-phosphate dehydrogenaseG6P, Glucose-6-phosphateGCK, GlucokinaseGlucoregulatory enzymesGlucose metabolitesGLUT, Glucose transporterGlycogenGSIS, glucose-stimulated insulin secretionHClO4, Perchloric acidHRP, Horseradish PeroxidaseIMGU, Insulin-mediated glucose uptakeInsulinKOH, Potassium hydroxideLDH, Lactate dehydrogenaseMCT, Monocarboxylate transportersNAD, Nicotinamide adenine dinucleotideNHTO, N-hexane TO fractionPlasma glucoseSEM, Standard error of meanTCA, Tricarboxylic acid cycleTelfairia occidentalisTO, Telfairia occidentalis

Identifiers

PMID33997754
PMCPMC8095178
OpenAlexW3155032371

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.