Evidence map›Paper›PMID 34002501›Full record

ArticleWorld psychiatry : official journal of the World Psychiatric Association (WPA)2021

Efficacy and acceptability of pharmacological, psychosocial, and brain stimulation interventions in children and adolescents with mental disorders: an umbrella review.

Christoph U Correll, Samuele Cortese, Giovanni Croatto, Francesco Monaco, Damir Krinitski, Gonzalo Arrondo, Edoardo G Ostinelli, Caroline Zangani, Michele Fornaro, Andrés Estradé and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in World psychiatry : official journal of the World Psychiatric Association (WPA), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 20 pooled it
16.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 20 syntheses or guidelines pooled it, 141 citations in OpenAlex.

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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 12 institutions in 8 countries.

Christoph U CorrellDepartment of Psychiatry, Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York, NY, USA.
Samuele CorteseCenter for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.
Giovanni CroattoNeurosciences Department, University of Padua, Padua, Italy.
Francesco MonacoDepartment of Mental Health, ASL Salerno, Salerno, Italy.
Damir KrinitskiIntegrated Psychiatry Winterthur, Winterthur, Switzerland.
Gonzalo ArrondoCenter for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.
Edoardo G OstinelliPsychiatry Department, Oxford University, Oxford, UK.
Caroline ZanganiDepartment of Health Sciences, University of Milan, Milan, Italy.
Michele FornaroDepartment of Psychiatry, Federico II University, Naples, Italy.
Andrés EstradéEarly Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Paolo Fusar-PoliEarly Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Andre F CarvalhoDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
Marco SolmiNeurosciences Department, University of Padua, Padua, Italy.
King's College London · GBFederico II University Hospital · ITKantonsspital Winterthur · CHNew York University · USNorthwell Health · USScience Oxford · GBUniversidad Católica del Uruguay · UYUniversidad de Navarra · ESUniversity of Milan · ITUniversity of Padua · ITUniversity of Salerno · ITUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Top-tier evidence on the safety/tolerability of 80 medications in children/adolescents with mental disorders has recently been reviewed in this jour-nal. To guide clinical practice, such data must be combined with evidence on efficacy and acceptability. Besides medications, psychosocial inter-ventions and brain stimulation techniques are treatment options for children/adolescents with mental disorders. For this umbrella review, we systematically searched network meta-analyses (NMAs) and meta-analyses (MAs) of randomized controlled trials (RCTs) evaluating 48 medications, 20 psychosocial interventions, and four brain stimulation techniques in children/adolescents with 52 different mental disorders or groups of mental disorders, reporting on 20 different efficacy/acceptability outcomes. Co-primary outcomes were disease-specific symptom reduction and all-cause discontinuation ("acceptability"). We included 14 NMAs and 90 MAs, reporting on 15 mental disorders or groups of mental disorders. Overall, 21 medications outperformed placebo regarding the co-primary outcomes, and three psychosocial interventions did so (while seven outperformed waiting list/no treatment). Based on the meta-analytic evidence, the most convincing efficacy profile emerged for amphetamines, methylphenidate and, to a smaller extent, behavioral therapy in attention-deficit/hyperactivity disorder; aripiprazole, risperidone and several psychosocial interventions in autism; risperidone and behavioral interventions in disruptive behavior disorders; several antipsychotics in schizophrenia spectrum disorders; fluoxetine, the combination of fluoxetine and cognitive behavioral therapy (CBT), and interpersonal therapy in depression; aripiprazole in mania; fluoxetine and group CBT in anxiety disorders; fluoxetine/selective serotonin reuptake inhibitors, CBT, and behavioral therapy with exposure and response prevention in obsessive-compulsive disorder; CBT in post-traumatic stress disorder; imipramine and alarm behavioral intervention in enuresis; behavioral therapy in encopresis; and family therapy in anorexia nervosa. Results from this umbrella review of interventions for mental disorders in children/adolescents provide evidence-based information for clinical decision making.

Indexed as

acceptabilityADHDadolescentsautismbrain stimulationChildrendis­ruptive behavior disordersefficacypharmacotherapypsychosocial interventionspsychotherapies

Identifiers

PMID34002501
PMCPMC8129843
OpenAlexW3162418457

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.