Evidence map›Paper›PMID 34006247›Full record

SynthesisBMC cancer2021

Association of single nucleotide polymorphisms of cytochrome P450 enzymes with experience of vasomotor, vaginal and musculoskeletal symptoms among breast cancer patients: a systematic review.

Carmen W H Chan, Bernard M H Law, Marques S N Ng, Corinna C Y Wong, Carissa W Y Wong, Morgan Quinley, Jessica M Orgusyan, Ka Ming Chow, Mary M Y Waye

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. The Employment of GeneraNutrients · 2022
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Carmen W H ChanThe Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, the New Territories, Hong Kong SAR, China.
Bernard M H LawThe Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, the New Territories, Hong Kong SAR, China.
Marques S N NgThe Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, the New Territories, Hong Kong SAR, China.
Corinna C Y WongUniversity College London School of Pharmacy, London, UK.
Carissa W Y WongUniversity College London Cancer Institution, University College London, London, UK.
Morgan QuinleyMolecular, Cell & Development Biology, University of California, Santa Cruz, USA.
Jessica M OrgusyanDepartment of Global Health, University of California, San Diego, USA.
Ka Ming ChowThe Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, the New Territories, Hong Kong SAR, China. kmchow@cuhk.edu.hk.ORCID http://orcid.org/0000-0002-7442-5197
Mary M Y WayeThe Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, the New Territories, Hong Kong SAR, China.
Chinese University of Hong Kong · HKLondon Cancer · GBUniversity of California San Diego · USUniversity of California, Santa Cruz · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdjuvant endocrine therapies are known to induce undesirable adverse effects such as vasomotor, vaginal and musculoskeletal symptoms among breast cancer patients. Drugs used in these therapies are often metabolised by cytochrome P450 (CYP) enzymes, in which their metabolising activities can be modified by single nucleotide polymorphisms (SNP) in CYP genes and CYP genotypes. This review aims to explore whether SNPs or genotypes of CYP are associated with the occurrence, frequency and severity of vasomotor, vaginal and musculoskeletal symptoms in breast cancer patients on adjuvant endocrine therapies.

methodsA literature review was conducted using five electronic databases, resulting in the inclusion of 14 eligible studies, and their findings were presented narratively. Selected items from the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist were used for critical appraisal of the reporting quality of the included studies.

resultsMost of the included studies showed that SNPs or genotypes of CYP that modify its metabolising activity have no effect on the occurrence, frequency or severity of vasomotor symptoms, including hot flashes. One study showed no correlation of these genetic variations in CYP with musculoskeletal symptoms, and no data were available on the association between such genetic variations and vaginal symptoms.

conclusionsOverall, genetic variations in CYP have no effect on the experience of hot flashes among breast cancer patients. We recommend exploration of the link between the active metabolites of chemotherapeutic drugs and the molecules shown to affect the occurrence or severity of hot flashes, and the establishment of the relationship between such genetic variations and patients' experience of musculoskeletal and vaginal symptoms. Subgroup analyses based on patients' duration of adjuvant endocrine therapies in such studies are recommended.

Indexed as

Antineoplastic Agents, HormonalArthralgiaAtrophyBreast NeoplasmsChemotherapy, AdjuvantCytochrome P-450 Enzyme SystemEstrogen AntagonistsEstrogensFemaleGenetic Predisposition to DiseaseHot FlashesHumansMastectomyObservational Studies as TopicPolymorphism, Single NucleotideSeverity of Illness Index4-hydroxy-N-desmethyltamoxifenAntineoplastic Agents, HormonalCytochrome P-450 Enzyme SystemEstrogen AntagonistsEstrogensTamoxifenAdjuvant endocrine therapyBreast cancer patientsCytochrome P450GenotypeSingle nucleotide polymorphismsSymptom

Identifiers

PMID34006247
PMCPMC8130378
OpenAlexW3163472743

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.