Evidence map›Paper›PMID 34011313›Full record

ArticleBMC nephrology2021

Guidelines adherence in the prevention and management of chronic kidney disease in patients with diabetes mellitus on the background of recent European recommendations - a registry-based analysis.

Peter Bramlage, Stefanie Lanzinger, Sascha R Tittel, Eva Hess, Simon Fahrner, Christoph H J Heyer, Mathias Friebe, Ivo Buschmann, Thomas Danne, Jochen Seufert and 1 more

Open access · goldAbstract read
In one paragraph

Article in BMC nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  6. Care Processes and Clinical Responses to Newly Detected Albuminuria: The Stockholm Creatinine Measurements (SCREAM) Project.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026
    Article
  7. Article
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  9. Systematic Literature Review of the Impact of Type 2 Diabetes and Heart Failure Guideline Adherence on Clinical and Economic Outcomes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Peter BramlageInstitute for Pharmacology and Preventive Medicine, Bahnhofstrasse 20, 49661, Cloppenburg, Germany. peter.bramlage@ippmed.de.
Stefanie LanzingerInstitute for Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany.
Sascha R TittelInstitute for Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany.
Eva HessSpecialized Diabetes Practice Dres. Hess, Worms, Germany.
Simon FahrnerMedical Clinic, SRH Clinic Sigmaringen, Pfullendorf, Germany.
Christoph H J HeyerSpecialized Diabetes Practice Viersen, Viersen, Germany.
Mathias FriebeProtestant Hospital, Oberhausen, Germany.
Ivo BuschmannDAZB (German Angiology Center Brandenburg/Berlin), Medical School Brandenburg (MHB) & Faculty of Health Science FGW, Brandenburg, Germany.
Thomas DanneKinderkrankenhaus auf der Bult, Diabetes Centre for Children and Adolescents, Hannover, Germany.
Jochen SeufertDivision of Endocrinology and Diabetology, Department of Medicine II, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Reinhard W HollInstitute for Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany.
Universität Ulm · DEEvangelisches Krankenhaus Oberhausen · DEIPPMed (Germany) · DEKinderkrankenhaus auf der Bult · DELVR-Klinik für Orthopädie Viersen · DEUniversitätsklinikum Brandenburg an der Havel · DEUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent European Society of Cardiology (ESC)/European Association for the Study of Diabetes (EASD) guidelines provide recommendations for detecting and treating chronic kidney disease (CKD) in diabetic patients. We compared clinical practice with guidelines to determine areas for improvement.

methodsGerman database analysis of 675,628 patients with type 1 or type 2 diabetes, with 134,395 included in this analysis. Data were compared with ESC/EASD recommendations.

resultsThis analysis included 17,649 and 116,747 patients with type 1 and type 2 diabetes, respectively. The analysis showed that 44.1 and 49.1 % patients with type 1 and type 2 diabetes, respectively, were annually screened for CKD. Despite anti-diabetic treatment, only 27.2 % patients with type 1 and 43.5 % patients with type 2 achieved a target HbA1c of < 7.0 %. Use of sodium-glucose transport protein 2 inhibitors (1.5 % type 1/8.7 % type 2 diabetes) and glucagon-like peptide-1 receptor agonists (0.6 % type 1/5.2 % type 2 diabetes) was limited. Hypertension was controlled according to guidelines in 41.1 and 67.7 % patients aged 18-65 years with type 1 and 2 diabetes, respectively, (62.4 vs. 68.4 % in patients > 65 years). Renin angiotensin aldosterone inhibitors were used in 24.0 and 40.9 % patients with type 1 diabetes (micro- vs. macroalbuminuria) and 39.9 and 47.7 %, respectively, in type 2 diabetes.

conclusionsData indicate there is room for improvement in caring for diabetic patients with respect to renal disease diagnosis and treatment. While specific and potentially clinically justified reasons for non-compliance exist, the data may serve well for a critical appraisal of clinical practice decisions.

Indexed as

Guideline AdherenceAdultAgedAntihypertensive AgentsDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic NephropathiesFemaleGlycated HemoglobinHumansHypertensionHypoglycemic AgentsMaleMiddle AgedPractice Guidelines as TopicRegistriesAntihypertensive AgentsGlycated Hemoglobinhemoglobin A1c protein, humanHypoglycemic AgentsSodium-Glucose Transporter 2 Inhibitorsalbuminuriachronic kidney diseasediabetesdiagnosticsglomerular filtration ratehypertensionpharmacotherapy

Identifiers

PMID34011313
PMCPMC8135159
OpenAlexW3161914077

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.