Evidence map›Paper›PMID 34012003›Full record

ArticleScientific reports2021

Assessment of select synthetic cannabinoid receptor agonist bias and selectivity between the type 1 and type 2 cannabinoid receptor.

Ayat Zagzoog, Asher L Brandt, Tallan Black, Eunhyun D Kim, Riley Burkart, Mikin Patel, Zhiyun Jin, Maria Nikolaeva, Robert B Laprairie

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

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  20. Frontiers in neuroscience · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ayat ZagzoogCollege of Pharmacy and Nutrition, University of Saskatchewan, 3B36, Health Sciences Building, 104 Clinic Place, Saskatoon, SK, S7N 5E5, Canada.
Asher L BrandtCollege of Pharmacy and Nutrition, University of Saskatchewan, 3B36, Health Sciences Building, 104 Clinic Place, Saskatoon, SK, S7N 5E5, Canada.
Tallan BlackCollege of Pharmacy and Nutrition, University of Saskatchewan, 3B36, Health Sciences Building, 104 Clinic Place, Saskatoon, SK, S7N 5E5, Canada.
Eunhyun D KimCollege of Pharmacy and Nutrition, University of Saskatchewan, 3B36, Health Sciences Building, 104 Clinic Place, Saskatoon, SK, S7N 5E5, Canada.
Riley BurkartCollege of Pharmacy and Nutrition, University of Saskatchewan, 3B36, Health Sciences Building, 104 Clinic Place, Saskatoon, SK, S7N 5E5, Canada.
Mikin PatelHealth Canada, Ottawa, ON, Canada.
Zhiyun JinHealth Canada, Ottawa, ON, Canada.
Maria NikolaevaHealth Canada, Ottawa, ON, Canada.
Robert B LaprairieCollege of Pharmacy and Nutrition, University of Saskatchewan, 3B36, Health Sciences Building, 104 Clinic Place, Saskatoon, SK, S7N 5E5, Canada. robert.laprairie@usask.ca.
University of Saskatchewan · CAHealth Canada · CADalhousie University · CA

Funding

CIHR 387577
6 · The paper itself

Abstract

The first synthetic cannabinoid receptor agonists (SCRAs) were designed as tool compounds to study the endocannabinoid system's two predominant cannabinoid receptors, CB1R and CB2R. Unfortunately, novel SCRAs now represent the most rapidly proliferating novel psychoactive substances (NPS) of abuse globally. Unlike ∆

Indexed as

Animalsbeta-Arrestin 2Body TemperatureCannabinoid Receptor AgonistsCatalepsyCHO CellsColforsinCricetulusCyclic AMPHumansMaleMiceMice, Inbred C57BLModels, MolecularNociceptionReceptor, Cannabinoid, CB1beta-Arrestin 2Cannabinoid Receptor AgonistsColforsinCyclic AMPReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2

Identifiers

PMID34012003
PMCPMC8134483
OpenAlexW3161273037

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.