Evidence map›Paper›PMID 34012421›Full record

SynthesisFrontiers in endocrinology2021

The Effects of Curcumin on Diabetes Mellitus: A Systematic Review.

Ledyane Taynara Marton, Laís Maria Pescinini-E-Salzedas, Maria Eduarda Côrtes Camargo, Sandra M Barbalho, Jesselina F Dos Santos Haber, Renata Vargas Sinatora, Claudia Rucco Penteado Detregiachi, Raul J S Girio, Daniela Vieira Buchaim, Patricia Cincotto Dos Santos Bueno

Registry-linked trialOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07436130 (Immunomodulatory Effect of Curcumin in Critically Ill Patients With Sepsis at the Antiguo Hospital Civil de Guadalajara "Fray Antonio Alcalde"), which is not on this map. Cited by 95 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 6 pooled it
8.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07436130 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Immunomodulatory Effect of Curcumin in Critically Ill Patients With Sepsis at the Antiguo Hospital Civil de Guadalajara "Fray Antonio Alcalde": A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

TypeinterventionalSponsorHospital Civil de GuadalajaraRan2026 to 2027Enrolled56ConditionsSepsisArmsCurcumin, Placebo
3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 6 syntheses or guidelines pooled it, 191 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. The metabolic effect ofFrontiers in nutrition · 2023
    Pooled it
  7. Effects ofFrontiers in nutrition · 2026
    Trial
  8. Trial
  9. Review
  10. Curcumin Targets Crispld2 to Suppress Hepatic Stellate Cell Activation via PI3K/AKT Pathway Inhibition in Hepatic Fibrosis.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Curcumin Between Pleiotropic Potential and Translational Constraints.International journal of molecular sciences · 2026
    Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ledyane Taynara MartonDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, Brazil.
Laís Maria Pescinini-E-SalzedasDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, Brazil.
Maria Eduarda Côrtes CamargoDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, Brazil.
Sandra M BarbalhoDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, Brazil.
Jesselina F Dos Santos HaberDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, Brazil.
Renata Vargas SinatoraDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, Brazil.
Claudia Rucco Penteado DetregiachiPostgraduate Program in Structural and Functional Interactions in Rehabilitation-UNIMAR, Marília, Brazil.
Raul J S GirioDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, Brazil.
Daniela Vieira BuchaimDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, Brazil.
Patricia Cincotto Dos Santos BuenoDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, Brazil.
Universidade de Marília · BRFaculdade de Medicina de Marília · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus (DM) is an ensemble of metabolic conditions that have reached pandemic proportions worldwide. Pathology's multifactorial nature makes patient management, including lifelong drug therapy and lifestyle modification, extremely challenging. Currently, there is growing evidence about the effectiveness of using herbal supplements in preventing and controlling DM. Curcumin is a bioactive component found

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalCurcuminDiabetes MellitusHumansAnti-Inflammatory Agents, Non-SteroidalCurcuminCurcuma longacurcumincurcuminoidsdiabetestype 2 diabetes mellitus

Identifiers

PMID34012421
PMCPMC8126655
OpenAlexW3159217912

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.