ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2022
Sensitivity of T1/T2-weighted ratio in detection of cortical demyelination is similar to magnetization transfer ratio using post-mortem MRI.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Intensity scaling of conventional brain magnetic resonance images avoiding cerebral reference regions: A systematic review.PloS one · 2024Pooled it
- Assessment of Optimal T1/T2-Weighted Combinations for Myelin Sensitivity: Effects of Echo Time and Exponents.Magnetic resonance in medicine · 2026Article
- T1-weighted/T2-weighted ratio reflects microstructural changes in Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Whole-brain in situ postmortem MR imaging using a combination of sequences for cortical lesion detection in multiple sclerosis.La Radiologia medica · 2026Article
- Humans have a longer period of cortical maturation across depth and hierarchy than macaques.PLoS biology · 2025Article
- Mediation of the association between disadvantaged neighborhoods and cortical microstructure by body mass index.Communications medicine · 2023Article
- Emerging Perspectives on MRI Application in Multiple Sclerosis: Moving from Pathophysiology to Clinical Practice.Radiology · 2023Review
- Cortical amyloid-beta burden is associated with changes in intracortical myelin in cognitively normal older adults.Translational psychiatry · 2023Article
- Effects of non-modifiable risk factors of Alzheimer's disease on intracortical myelin content.Alzheimer's research & therapy · 2022Article
- GdProceedings of the National Academy of Sciences of the United States of America · 2022Article
- T1/T2-weighted ratio is a surrogate marker of demyelination in multiple sclerosis: No.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Chronic cerebral hypoperfusion-induced myelin loss in normal-appearing white matter correlates with cognitive decline: insights from moyamoya disease.Alzheimer's & dementia (New York, N. Y.)Article
- TJournal of neuroimaging : official journal of the American Society of NeuroimagingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDetecting cortical demyelination using magnetic resonance imaging (MRI) in multiple sclerosis (MS) remains a challenge. Magnetization transfer ratio (MTR), T1-weighted/T2-weighted ratio (T1T2R), and T2-weighted (T2w) signal are sensitive to cortical demyelination, but their accuracy is unknown.
objectivesTo quantify the sensitivity, specificity, and accuracy of postmortem T1T2R, MTR, and T2w in detecting cortical demyelination.
methods
resultsThe mean age (standard deviation) at death was 64.7 (+/-13.7) years with a disease duration of 23.8 (+/-10.5) years. The sensitivity was 78% for MTR, 75% for T1T2R, and 63% for T2w. The specificity was 46% (T2w), 13% (T1T2R), and 29% (MTR). The accuracy was 71% (T2w), 39% (MTR), and 42% (T1T2R). There were no significant differences between different MRI measures in cortical demyelination or intracortical/subpial lesion detection.
conclusionsAlthough somewhat sensitive, the modest specificity of conventional MRI modalities for cortical demyelination indicates that they are influenced by cortical changes other than demyelination. Improved acquisition and post-processing are needed to reliably measure cortical lesion load.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.