Evidence map›Paper›PMID 34018358›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2021

[The Mechanism of GREM1's Effect on Osteogenic/Odontogenic Differentiation of Stem Cells from Apical Papilla].

Xing-Yan Zhu, Shu Diao, Dong-Mei Yang, Zhi-Peng Fan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xing-Yan ZhuDepartment of Dentistry, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
Shu DiaoDepartment of Pediatric Dentistry, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China.
Dong-Mei YangDepartment of Pediatric Dentistry, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China.
Zhi-Peng FanBeijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Research Institute of Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China.
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study the effect of bone morphogenetic protein (BMP) antagonist Gremlin 1 (GREM1) on the function of stem cells from apical papilla (SCAPs) and explore its mechanism.

methodsAfter isolation and culturing of stem cells from apical papilla

resultsImmunofluorescence staining showed that the expression of GREM1 in the nucleus was higher than that in the cytoplasm. Real time-PCR and Western blot affirmed that

conclusionsThe knockdown of

Indexed as

OdontogenesisOsteogenesisCell DifferentiationCell ProliferationCells, CulturedStem CellsBone morphogenetic proteinGREM1Osteogenic/odontogenic differentiationStem cells from the apical papilla

Identifiers

PMID34018358
PMCPMC10409195
OpenAlexW3161943894

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.