Evidence mapPaperPMID 34020394Full record

ReviewInternational immunopharmacology2021

Insights on the mechanisms of action of ozone in the medical therapy against COVID-19.

Salvatore Chirumbolo, Luigi Valdenassi, Vincenzo Simonetti, Dario Bertossi, Giovanni Ricevuti, Marianno Franzini, Sergio Pandolfi

Abstract readReview
In one paragraph

Review in International immunopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Is the increased ozone dosage key factor for its anti-inflammatory effect in an experimental model of mesenteric ischemia?Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2023
    Article
  14. The Hidden Pandemic of COVID-19-Induced Organizing Pneumonia.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Salvatore ChirumboloDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy. Electronic address: salvatore.chirumbolo@univr.it.
Luigi ValdenassiSIOOT, High School in Oxygen Ozone Therapy, University of Pavia, Italy; SIOOT INTERNATIONAL, Communian Clinic, Gorle Bergamo, Italy.
Vincenzo SimonettiSIOOT, High School in Oxygen Ozone Therapy, University of Pavia, Italy; SIOOT INTERNATIONAL, Communian Clinic, Gorle Bergamo, Italy.
Dario BertossiDepartment of Surgery, Dentistry, Paediatrics and Gynaecology Unit of Maxillo-Facial Surgery University of Verona, Verona, Italy.
Giovanni RicevutiDepartment of Drug Science, University of Pavia, Italy.
Marianno FranziniSIOOT, High School in Oxygen Ozone Therapy, University of Pavia, Italy; SIOOT INTERNATIONAL, Communian Clinic, Gorle Bergamo, Italy.
Sergio PandolfiSIOOT, High School in Oxygen Ozone Therapy, University of Pavia, Italy; SIOOT INTERNATIONAL, Communian Clinic, Gorle Bergamo, Italy; Villa Mafalda Clinics via Monte delle Gioie, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An increasing amount of reports in the literature is showing that medical ozone (O

Indexed as

COVID-19 Drug TreatmentHumansOxidants, PhotochemicalOxidative StressOzoneSARS-CoV-2Oxidants, PhotochemicalOzoneAnti-inflammatoryAnti-oxidantCOVID-19Medical therapyOzone therapyReview

Identifiers

PMID34020394
PMCPMC8112288

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.