Evidence map›Paper›PMID 34021086›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Elementary mechanisms of calmodulin regulation of Na

Po Wei Kang, Nourdine Chakouri, Johanna Diaz, Gordon F Tomaselli, David T Yue, Manu Ben-Johny

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

  1. Late IMedicinal research reviews · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Calcium interaction with Nav1.5 via FGF12A and CaM binding.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Calmodulin Mutations in Human Disease.Channels (Austin, Tex.) · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. BIOLOGICAL ANTIARRHYTHMICS-SODIUM CHANNEL INTERACTING PROTEINS.Transactions of the American Clinical and Climatological Association · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Po Wei KangDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218; kang.powei@wustl.edu mbj2124@cumc.columbia.edu.ORCID 0000-0002-5933-545X
Nourdine ChakouriDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032.ORCID 0000-0002-8809-8684
Johanna DiazDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032.
Gordon F TomaselliDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.
David T YueDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218.
Manu Ben-JohnyDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218; kang.powei@wustl.edu mbj2124@cumc.columbia.edu.
Johns Hopkins University · USColumbia University · USAlbert Einstein College of Medicine · US

Funding

Calmodulin Regulation Na Channels: From Function and Structure to DiseaseR01HL128743 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ALDRICH, RICHARD, AMZEL, L. MARIO · 2016 to 2019
$4.2M
Tuning of CaV channel dynamics by stac proteinsR01NS110672 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JOHNY, MANU BEN · 2019 to 2023
$1.7M
Becton Dickinson LSR II Analytical Flow CytometerS10RR027050 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLYNES, RAPHAEL A. · 2011 to 2011
$413k
NCRR NIH HHS S10 RR027050NHLBI NIH HHS R01 HL128743NINDS NIH HHS R01 NS110672
6 · The paper itself

Abstract

In cardiomyocytes, Na

Indexed as

Action PotentialsArrhythmias, CardiacBinding SitesCalciumCalcium SignalingCalmodulinFluorescence Resonance Energy TransferGene ExpressionHEK293 CellsHumansIon Channel GatingKineticsModels, MolecularMutationMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelCalciumCalmodulinNAV1.5 Voltage-Gated Sodium ChannelRecombinant ProteinsSCN5A protein, humanSodiumBrugada syndromecalmodulinion channelslong QT syndromeNav1.5

Identifiers

PMID34021086
PMCPMC8166197
OpenAlexW3162553885

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.