Evidence map›Paper›PMID 34024124›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Sex and the G Protein-Coupled Estrogen Receptor Impact Vascular Stiffness.

Benard O Ogola, Gabrielle L Clark, Caleb M Abshire, Nicholas R Harris, Kaylee L Gentry, Shreya S Gunda, Isabella Kilanowski-Doroh, Tristen J Wong, Bruna Visniauskas, Dylan J Lawrence and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. External Validation and Local Adaptation of Estimated Pulse Wave Velocity Models in a Brazilian Population.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
    Article
  4. Review
  5. The impact of age and sex on cerebral and large artery stiffness and the response to pulse pressure.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Hypertension disrupts the vascular clock in both sexes.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  12. Article
  13. Article
  14. Effects of dietary soy content on cerebral artery function and behavior in ovariectomized female mice.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Sex differences in vascular aging and impact of GPER deletion.American journal of physiology. Heart and circulatory physiology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Benard O OgolaDepartment of Pharmacology (B.O.O., C.M.A., N.R.H., K.L.G., S.S.G., I.K.-D., T.J.W., B.V., M.A.Z., S.H.L.), Tulane University, New Orleans, LA.
Gabrielle L ClarkDepartment of Biomedical Engineering (G.L.C., D.J.L., C.L.B., K.S.M.), Tulane University, New Orleans, LA.
Caleb M AbshireDepartment of Pharmacology (B.O.O., C.M.A., N.R.H., K.L.G., S.S.G., I.K.-D., T.J.W., B.V., M.A.Z., S.H.L.), Tulane University, New Orleans, LA.
Nicholas R HarrisDepartment of Pharmacology (B.O.O., C.M.A., N.R.H., K.L.G., S.S.G., I.K.-D., T.J.W., B.V., M.A.Z., S.H.L.), Tulane University, New Orleans, LA.
Kaylee L GentryDepartment of Pharmacology (B.O.O., C.M.A., N.R.H., K.L.G., S.S.G., I.K.-D., T.J.W., B.V., M.A.Z., S.H.L.), Tulane University, New Orleans, LA.
Shreya S GundaDepartment of Pharmacology (B.O.O., C.M.A., N.R.H., K.L.G., S.S.G., I.K.-D., T.J.W., B.V., M.A.Z., S.H.L.), Tulane University, New Orleans, LA.
Isabella Kilanowski-DorohDepartment of Pharmacology (B.O.O., C.M.A., N.R.H., K.L.G., S.S.G., I.K.-D., T.J.W., B.V., M.A.Z., S.H.L.), Tulane University, New Orleans, LA.
Tristen J WongDepartment of Pharmacology (B.O.O., C.M.A., N.R.H., K.L.G., S.S.G., I.K.-D., T.J.W., B.V., M.A.Z., S.H.L.), Tulane University, New Orleans, LA.
Bruna VisniauskasDepartment of Pharmacology (B.O.O., C.M.A., N.R.H., K.L.G., S.S.G., I.K.-D., T.J.W., B.V., M.A.Z., S.H.L.), Tulane University, New Orleans, LA.
Dylan J LawrenceDepartment of Biomedical Engineering (G.L.C., D.J.L., C.L.B., K.S.M.), Tulane University, New Orleans, LA.
Margaret A ZimmermanDepartment of Pharmacology (B.O.O., C.M.A., N.R.H., K.L.G., S.S.G., I.K.-D., T.J.W., B.V., M.A.Z., S.H.L.), Tulane University, New Orleans, LA.
Carolyn L BayerDepartment of Biomedical Engineering (G.L.C., D.J.L., C.L.B., K.S.M.), Tulane University, New Orleans, LA.
Leanne GrobanDepartment of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC (L.G.).
Kristin S MillerDepartment of Biomedical Engineering (G.L.C., D.J.L., C.L.B., K.S.M.), Tulane University, New Orleans, LA.
Sarah H LindseyDepartment of Pharmacology (B.O.O., C.M.A., N.R.H., K.L.G., S.S.G., I.K.-D., T.J.W., B.V., M.A.Z., S.H.L.), Tulane University, New Orleans, LA.
Tulane University · USWake Forest University · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Eliciting Estrogen's Protective Vascular EffectsR01HL133619 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI LINDSEY, SARAH H. · 2017 to 2021
$2.2M
Placental Functional Imaging to Predict Preeclampsia Therapeutic OutcomesR01HD097466 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI BAYER, CAROLYN LOUISE · 2019 to 2023
$1.6M
Effects of cell-based hormone therapy on LV diastolic dysfunction and hypertrophy progression after mid-life estrogen lossR21AG061588 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GROBAN, LEANNE, OPARA, EMMANUEL C. · 2019 to 2020
$436k
NHLBI NIH HHS R01 HL133619NIA NIH HHS R21 AG061588NICHD NIH HHS R01 HD097466NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AnimalsBlood PressureCarotid ArteriesEchocardiographyFemaleGenotypeHumansMaleMiceMice, KnockoutPhenotypePulse Wave AnalysisReceptors, EstrogenReceptors, G-Protein-CoupledSex FactorsVascular StiffnessReceptors, EstrogenReceptors, G-Protein-Coupledblood pressureestrogensmenopausesexvascular remodeling

Identifiers

PMID34024124
PMCPMC8192475
OpenAlexW3165672341

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.