Evidence map›Paper›PMID 34024274›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2021

Impact of pulmonary valve replacement on left ventricular rotational mechanics in repaired tetralogy of Fallot.

Jamie K Harrington, Sunil Ghelani, Nikhil Thatte, Anne Marie Valente, Tal Geva, Julia A Graf, Minmin Lu, Lynn A Sleeper, Andrew J Powell

Open access · goldAbstract read
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Ventricular dyssynchrony late after the Fontan operation is associated with decreased survival.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Article
  3. Article
  4. Impact of pulmonary valve replacement on left and right ventricular function using strain analysis, in children with repaired tetralogy of Fallot.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jamie K HarringtonDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA. Jh3213@cumc.columbia.edu.ORCID 0000-0002-2220-4712
Sunil GhelaniDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Nikhil ThatteDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Anne Marie ValenteDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Tal GevaDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Julia A GrafDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Minmin LuDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Lynn A SleeperDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Andrew J PowellDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Boston Children's Hospital · USBrigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn repaired tetralogy of Fallot (rTOF), abnormal left ventricular (LV) rotational mechanics are associated with adverse clinical outcomes. We performed a comprehensive analysis of LV rotational mechanics in rTOF patients using cardiac magnetic resonance (CMR) prior to and following surgical pulmonary valve replacement (PVR).

methodsIn this single center retrospective study, we identified rTOF patients who (1) had both a CMR ≤ 1 year before PVR and ≤ 5 years after PVR, (2) had no other intervening procedure between CMRs, (3) had a body surface area > 1.0 m

resultsA total of 60 rTOF patients (23.6 ± 7.9 years, 52% male) and 30 healthy control subjects (20.8 ± 3.1 years, 50% male) were included. Compared with healthy controls, rTOF patients had lower apical and basal rotation, twist, torsion, and systolic rotation rates, and these parameters peaked earlier in systole. The only parameters that were correlated with LV torsion were right ventricular (RV) end-systolic volume (r = - 0.28, p = 0.029) and RV ejection fraction (r = 0.26, p = 0.044). At a median of 1.0 year (IQR 0.5-1.7) following PVR, there was no significant change in LV rotational parameters versus pre-PVR despite reductions in RV volumes, RV mass, pulmonary regurgitation, and RV outflow tract obstruction.

conclusionIn this comprehensive study of CMR-derived LV rotational mechanics in rTOF patients, rotation, twist, and torsion were diminished compared to controls and did not improve at a median of 1 year after PVR despite favorable RV remodeling.

Indexed as

Pulmonary ValvePulmonary Valve InsufficiencyTetralogy of FallotFemaleHumansMalePredictive Value of TestsRetrospective StudiesFeature trackingMagnetic resonance imagingPulmonary valve replacementRotational mechanicsTetralogy of FallotTorsionTwist

Identifiers

PMID34024274
PMCPMC8142485
OpenAlexW3164920847

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.