SynthesisFrontiers in cardiovascular medicine2021
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival Data.
Synthesis in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Periodontal disease and cardiovascular disease: umbrella review.BMC oral health · 2024Pooled it
- Oral frailty indicators to target major adverse health-related outcomes in older age: a systematic review.GeroScience · 2023Pooled it
- Efficacy of maxillary occlusal splints on mobile posterior teeth in patients with stage III or IV periodontitis during steps 1 and 2 of periodontal therapy: a randomized parallel-controlled clinical trial.Clinical oral investigations · 2025Trial
- Missing Teeth and Incident Cardiovascular Disease in Ageing Populations: Longitudinal Evidence from Three Nationally Representative Cohorts.Journal of clinical medicine · 2026Article
- Oral Health and Cardiovascular Disease Among Hypertensive Medicated Adults With Uncontrolled Blood Pressure.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Association Between Toothbrushing Habits and Mucosal Healing in Japanese Patients with Ulcerative Colitis.Digestive diseases and sciences · 2026Article
- Dental Anxiety as a Potential Bottleneck in Oral-Systemic Health Pathways: A Conceptual Mapping Review of Review Articles.Dentistry journal · 2026Review
- Estimating the Causal Effect of Tooth Loss on the Critical Outcome of COVID-19.JDR clinical and translational research · 2026Article
- Assessing the burden of oral health conditions in the German population: a focus on dental caries, periodontitis, and edentulism.BMC oral health · 2026Article
- Strong Heart, Strong Smile: Tooth Loss and Incidence of CVD in American Indian Populations.Community dentistry and oral epidemiology · 2026Article
- Blood and skin carotenoid levels are inversely associated with the prevalence of periodontal diseases in populations with normal occlusion: a cross-sectional analysis from the Iwaki health promotion project.Nutrition journal · 2026Article
- Impact of Tooth Loss on Heart Failure After Myocardial Infarction: A Cross-Sectional Study Bridging Oral and Cardiovascular Health.Dentistry journal · 2025Article
- Assessing the effectivity of counting the number of teeth with their conditions to predict mortality: the OHSAKA study.BMC oral health · 2025Article
- Tooth Loss and Cardiovascular Risk Burden in Myocardial Infarction Patients.Journal of clinical medicine · 2025Article
- Genome-wide association study of pulpal and apical diseases.Nature communications · 2025Article
- Oral Disease and Atherosclerosis May Be Associated with Overlapping Metabolic Pathways.JDR clinical and translational research · 2025Article
- Association between the number of teeth and all-cause mortality rate in the MASHAD Cohort Study.Journal of dental research, dental clinics, dental prospects · 2025Article
- Dental and oral health assessments in the German National Cohort (NAKO).BMC oral health · 2025Article
- Tooth loss trajectories and their association with all-cause mortality among older Chinese adults.Frontiers in oral health · 2025Article
- The Number of Remaining Teeth-A Predictability Factor for a Certain Type of Cardiovascular Condition in a Group of Hospitalized Individuals.Journal of personalized medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tooth loss reflects the endpoint of two major dental diseases: dental caries and periodontitis. These comprise 2% of the global burden of human diseases. A lower number of teeth has been associated with various systemic diseases, in particular, atherosclerotic cardiovascular diseases (ACVD). The aim was to summarize the evidence of tooth loss related to the risk for ACVD or death. Cohort studies with prospective follow-up data were retrieved from Medline-PubMed and EMBASE. Following the PRISMA guidelines, two reviewers independently selected articles, assessed the risk of bias, and extracted data on the number of teeth (tooth loss; exposure) and ACVD-related events and all-cause mortality (ACM) (outcome). A total of 75 articles were included of which 44 were qualified for meta-analysis. A lower number of teeth was related to a higher outcome risk; the pooled risk ratio (RR) for the cumulative incidence of ACVD ranged from 1.69 to 2.93, and for the cumulative incidence of ACM, the RR ranged from 1.76 to 2.27. The pooled multiple adjusted hazard ratio (HR) for the incidence density of ACVD ranged from 1.02 to 1.21, and for the incidence density of ACM, the HR ranged from 1.02 to 1.30. This systematic review and meta-analyses of survival data show that a lower number of teeth is a risk factor for both ACVD and death. Health care professionals should use this information to inform their patients and increase awareness on the importance of good dental health and increase efforts to prevent tooth loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.