Evidence map›Paper›PMID 34027090›Full record

ReviewBioengineering & translational medicine2021

A review of biomarkers in the context of type 1 diabetes: Biological sensing for enhanced glucose control.

Kelilah L Wolkowicz, Eleonora M Aiello, Eva Vargas, Hazhir Teymourian, Farshad Tehrani, Joseph Wang, Jordan E Pinsker, Francis J Doyle, Mary-Elizabeth Patti, Lori M Laffel and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Bioengineering & translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
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  5. Review
  6. A closed-loop microneedle-integrated physiological model for predictive glycemic management.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
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  15. A Touch Enabled Hemodynamic and Metabolic Monitor.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  16. Review
  17. Review
  18. Development of a Novel Insulin Sensor for Clinical Decision-Making.Journal of diabetes science and technology · 2023
    Article
  19. Clinical Evaluation of a Novel Insulin Immunosensor.Journal of diabetes science and technology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Kelilah L WolkowiczHarvard John A. Paulson School of Engineering and Applied Sciences, Harvard University Cambridge Massachusetts USA.ORCID https://orcid.org/0000-0002-9788-3502
Eleonora M AielloHarvard John A. Paulson School of Engineering and Applied Sciences, Harvard University Cambridge Massachusetts USA.ORCID https://orcid.org/0000-0001-5129-8829
Eva VargasDepartment of Nanoengineering University of California San Diego La Jolla California USA.ORCID https://orcid.org/0000-0001-7634-5265
Hazhir TeymourianDepartment of Nanoengineering University of California San Diego La Jolla California USA.ORCID https://orcid.org/0000-0003-0025-4732
Farshad TehraniDepartment of Nanoengineering University of California San Diego La Jolla California USA.
Joseph WangDepartment of Nanoengineering University of California San Diego La Jolla California USA.ORCID https://orcid.org/0000-0002-4921-9674
Jordan E PinskerSansum Diabetes Research Institute Santa Barbara California USA.ORCID https://orcid.org/0000-0003-4080-9034
Francis J DoyleHarvard John A. Paulson School of Engineering and Applied Sciences, Harvard University Cambridge Massachusetts USA.ORCID https://orcid.org/0000-0002-3293-9114
Mary-Elizabeth PattiJoslin Diabetes Center, Harvard Medical School Boston Massachusetts USA.ORCID https://orcid.org/0000-0002-8163-3429
Lori M LaffelJoslin Diabetes Center, Harvard Medical School Boston Massachusetts USA.ORCID https://orcid.org/0000-0002-9675-3001
Eyal DassauHarvard John A. Paulson School of Engineering and Applied Sciences, Harvard University Cambridge Massachusetts USA.ORCID https://orcid.org/0000-0001-5333-6892
University of California San Diego · USHarvard University · USJoslin Diabetes Center · USSansum Diabetes Research Institute · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5M
NIDDK NIH HHS P30 DK036836
6 · The paper itself

Abstract

As wearable healthcare monitoring systems advance, there is immense potential for biological sensing to enhance the management of type 1 diabetes (T1D). The aim of this work is to describe the ongoing development of biomarker analytes in the context of T1D. Technological advances in transdermal biosensing offer remarkable opportunities to move from research laboratories to clinical point-of-care applications. In this review, a range of analytes, including glucose, insulin, glucagon, cortisol, lactate, epinephrine, and alcohol, as well as ketones such as beta-hydroxybutyrate, will be evaluated to determine the current status and research direction of those analytes specifically relevant to T1D management, using both in-vitro and on-body detection. Understanding state-of-the-art developments in biosensing technologies will aid in bridging the gap from bench-to-clinic T1D analyte measurement advancement.

Indexed as

automated insulin deliverybiosensorsmeasurementmedical devicesnanobiologytype 1 diabetes

Identifiers

PMID34027090
PMCPMC8126822
OpenAlexW3098571227

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.