ArticleMolecular systems biology2021
A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord.
Article in Molecular systems biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Comprehensive molecular profiling of combined hepatocellular carcinoma and cholangiocarcinoma reveals distinct Notch signaling subgroups with prognostic significance.Virchows Archiv : an international journal of pathology · 2026Article
- Spatial modelling of NOTCH signalling predicts tuneable dynamic heterogeneity in endothelia.NPJ systems biology and applications · 2026Article
- Oscillatory co-expression of HES1 and HES5 enables a hybrid state in a cross-repressive transcription factor regulatory motif.Development (Cambridge, England) · 2026Article
- HES1 oscillations are required for cell cycle reentry in oestrogen receptor-positive breast cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Keeping up with the neighbours: local synchronisation of cell fate decisions during development.EMBO reports · 2026Review
- Modes of Notch signalling in development and disease.Nature reviews. Molecular cell biology · 2025Review
- Cellular signalling protrusions enable dynamic distant contacts in spinal cord neurogenesis.Biology open · 2025Article
- Importance of ultradian oscillations in neurogenesis during development and its implications for spinal cord regeneration.Frontiers in cell and developmental biology · 2025Review
- Cell coupling compensates for changes in single-cell Her6 dynamics and provides phenotypic robustness.Development (Cambridge, England) · 2024Article
- Oscillatory control of embryonic development.Development (Cambridge, England) · 2024Review
- Cell state transitions: catch them if you can.Development (Cambridge, England) · 2023Article
- Dynamic switching of lateral inhibition spatial patterns.Journal of the Royal Society, Interface · 2022Article
- A lateral protrusion latticework connects neuroepithelial cells and is regulated during neurogenesis.Journal of cell science · 2022Article
- Signalling dynamics in embryonic development.The Biochemical journal · 2021Review
- A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord.Molecular systems biology · 2021Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Ultradian oscillations of HES Transcription Factors (TFs) at the single-cell level enable cell state transitions. However, the tissue-level organisation of HES5 dynamics in neurogenesis is unknown. Here, we analyse the expression of HES5 ex vivo in the developing mouse ventral spinal cord and identify microclusters of 4-6 cells with positively correlated HES5 level and ultradian dynamics. These microclusters are spatially periodic along the dorsoventral axis and temporally dynamic, alternating between high and low expression with a supra-ultradian persistence time. We show that Notch signalling is required for temporal dynamics but not the spatial periodicity of HES5. Few Neurogenin 2 cells are observed per cluster, irrespective of high or low state, suggesting that the microcluster organisation of HES5 enables the stable selection of differentiating cells. Computational modelling predicts that different cell coupling strengths underlie the HES5 spatial patterns and rate of differentiation, which is consistent with comparison between the motoneuron and interneuron progenitor domains. Our work shows a previously unrecognised spatiotemporal organisation of neurogenesis, emergent at the tissue level from the synthesis of single-cell dynamics.
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