Evidence map›Paper›PMID 34033792›Full record

ReviewCurrent biology : CB2021

The many roles of myosins in filopodia, microvilli and stereocilia.

Anne Houdusse, Margaret A Titus

Open access · greenAbstract readReview
In one paragraph

Review in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
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  5. Microvilli's grip on T cell development.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Quantifying bristle cell organization inbioRxiv : the preprint server for biology · 2025
    Article
  8. Modulation of Filopodial Myosin Function.bioRxiv : the preprint server for biology · 2025
    Article
  9. The filopodial myosin DdMyo7 is a slow, calcium-regulated motor.The Journal of biological chemistry · 2025
    Article
  10. Article
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  12. Mammalian oocytes receive maternal-effect RNAs from granulosa cells.bioRxiv : the preprint server for biology · 2025
    Article
  13. Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Anne HoudusseStructural Motility, Institut Curie, Paris Université Sciences et Lettres, Sorbonne Université, CNRS UMR144, 75005 Paris, France. Electronic address: Anne.Houdusse@curie.fr.
Margaret A TitusDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: titus004@umn.edu.
Centre National de la Recherche Scientifique · FRUniversity of Minnesota · US

Funding

Mechanism of myosin motor-dependent filopodia formationR01GM122917 · NIGMS · UNIVERSITY OF MINNESOTA · PI TITUS, MARGARET A · 2017 to 2024
$3.2M
NIGMS NIH HHS R01 GM122917
6 · The paper itself

Abstract

Filopodia, microvilli and stereocilia represent an important group of plasma membrane protrusions. These specialized projections are supported by parallel bundles of actin filaments and have critical roles in sensing the external environment, increasing cell surface area, and acting as mechanosensors. While actin-associated proteins are essential for actin-filament elongation and bundling in these protrusions, myosin motors have a surprising role in the formation and extension of filopodia and stereocilia and in the organization of microvilli. Actin regulators and specific myosins collaborate in controlling the length of these structures. Myosins can transport cargoes along the length of these protrusions, and, in the case of stereocilia and microvilli, interactions with adaptors and cargoes can also serve to anchor adhesion receptors to the actin-rich core via functionally conserved motor-adaptor complexes. This review highlights recent progress in understanding the diverse roles myosins play in filopodia, microvilli and stereocilia.

Indexed as

PseudopodiaStereociliaActinsMicrovilliMyosinsActinsMyosins

Identifiers

PMID34033792
PMCPMC8149809
OpenAlexW3164717649

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.