ArticleNature communications2021
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 59 citations in OpenAlex.
- NExON-Bayes: a Bayesian approach to network estimation informed by ordinal covariates.Bioinformatics (Oxford, England) · 2026Article
- PI3K/AKT signaling pathway: molecular crossroads in tumorigenesis and therapeutic innovation.Signal transduction and targeted therapy · 2026Review
- Multi-omics network inference with a Gaussian copula model.BMC bioinformatics · 2026Article
- Plasma extracellular vesicle proteomics nominates candidate biomarkers ofCell reports. Medicine · 2026Article
- Article
- Aryl hydrocarbon receptor promotes the proliferation and aggressive progression of colorectal cancer under high-fat diet via activating INPP4B/AKT/SGK3 signaling pathway.Frontiers in oncology · 2026Article
- Potential role of insulin-like growth factor 1 and growth hormone in acneiform eruptions: evidence from a rat model of acromegaly.Journal of endocrinological investigation · 2026Article
- Androgen deprivation-mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion.The Journal of clinical investigation · 2025Article
- Integrated transcriptomic and methylome analysis reveals retinoic acid pathway activation after decitabine treatment in EBV associated gastric cancer.bioRxiv : the preprint server for biology · 2025Article
- The IRF2-INPP4B Pathway Aggravates Acute Myeloid LeukemiaTurkish journal of haematology : official journal of Turkish Society of Haematology · 2025Article
- Lysosomal PIPProceedings of the National Academy of Sciences of the United States of America · 2025Article
- The essential clathrin adapter protein complex-2 is tumor suppressive specifically in vivo.Nature communications · 2025Article
- PTPN23-dependent activation of PI3KC2α is a therapeutic vulnerability of BRAF-mutant cancers.The Journal of experimental medicine · 2025Article
- Article
- Class I PI3Ks activate stretch-induced autophagy in trabecular meshwork cells.Cellular and molecular life sciences : CMLS · 2025Article
- Research advances in natural sesquiterpene lactones: overcoming cancer drug resistance through modulation of key signaling pathways.Cancer drug resistance (Alhambra, Calif.) · 2025Review
- Targeting the PI3K Pathway: Advancements and Achievements in Breast Cancer Therapy.Current pharmaceutical design · 2025Review
- INPP4B promotes PDAC aggressiveness via PIKfyve and TRPML-1-mediated lysosomal exocytosis.The Journal of cell biology · 2024Article
- Role of INPP4B in the proliferation, migration, invasion, and survival of human endometrial cancer cells.Histology and histopathology · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 8 institutions in 4 countries.
Samuel J RodgersCancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Lisa M OomsCancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0002-8918-9932
Viola M J OorschotMonash Ramaciotti Centre for Cryo Electron Microscopy, a Node of Microscopy Australia, Monash University, Victoria, Australia.
Ralf B SchittenhelmMonash Proteomics and Metabolomics Facility, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia.ORCID 0000-0001-8738-1878
Elizabeth V NguyenCancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Sabryn A HamilaCancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Natalie RynkiewiczDepartment of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia.
Rajendra GurungCancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Matthew J EramoCancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Absorn SriratanaCancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Clare G FedeleDepartment of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia.
Franco CaramiaPeter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC, Australia.ORCID 0000-0002-5086-2544
Sherene LoiPeter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC, Australia.ORCID 0000-0001-6137-9171
Genevieve KerrDevelopment and Stem Cells Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Helen E AbudDevelopment and Stem Cells Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0003-3792-4023
Georg RammCancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0003-3596-2288
Antonella PapaCancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0001-8653-7121
Andrew M EllisdonCancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Roger J DalyCancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0002-5739-8027
Catriona A McLeanDepartment of Anatomical Pathology, Alfred Hospital, Prahran, VIC, Australia.ORCID 0000-0002-0302-5727
Christina A MitchellCancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. christina.mitchell@monash.edu.ORCID 0000-0001-9372-3192
Australian Regenerative Medicine Institute · AUThe University of Melbourne · AUAustralian Research Council · AUBabraham Institute · GBDiscovery Institute · USEuropean Molecular Biology Laboratory · DEMonash University · AUThe Alfred Hospital · AU
Funding
No grant is acknowledged in the PubMed record.
Abstract
INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P
Indexed as
AnimalsAntineoplastic AgentsBreastBreast NeoplasmsCarcinogenesisCell Line, TumorCell ProliferationClass I Phosphatidylinositol 3-KinasesEndosomesFemaleGene Expression ProfilingHumansLysosomesMiceMutationPhosphatidylinositol PhosphatesAlpelisibAntineoplastic AgentsClass I Phosphatidylinositol 3-Kinasesphosphatidylinositol-3,4-bisphosphate 4-phosphatasephosphatidylinositol 3,4-diphosphatephosphatidylinositol 3-phosphatePhosphatidylinositol PhosphatesPhosphoric Monoester HydrolasesPIK3CA protein, humanrab7 GTP-Binding Proteinsrab7 GTP-binding proteins, humanrab7 GTP-binding proteins, mouserab GTP-Binding ProteinsThiazoles
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.