Evidence map›Paper›PMID 34039360›Full record

ArticleBMC medical genomics2021

In-vivo design feedback and perceived utility of a genetically-informed smoking risk tool among current smokers in the community.

Jessica L Bourdon, Amelia Dorsey, Maia Zalik, Amanda Pietka, Patricia Salyer, Michael J Bray, Laura J Bierut, Alex T Ramsey

Open access · goldAbstract read
In one paragraph

Article in BMC medical genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jessica L BourdonWellbridge Center for Addiction Treatment and Research, Center for Addiction Science, 525 Jan Way, Room 1523, Calverton, NY, 11922, USA. jbourdon@wellbridge.org.ORCID 0000-0002-7291-1431
Amelia DorseyDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
Maia ZalikDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
Amanda PietkaDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
Patricia SalyerDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
Michael J BrayDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
Laura J BierutDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
Alex T RamseyDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-3471-3725
Washington University in St. Louis · USAddiction Research Foundation · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI Shawn Shafer · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Transdisciplinary Training in Addictions ResearchT32DA015035 · NIDA · WASHINGTON UNIVERSITY · PI Leopoldo J Cabassa, Patricia A Cavazos-Rehg · 2002 to 2026
$5.3M
Washington University Career Development Program in Drug Abuse and AddictionK12DA041449 · NIDA · WASHINGTON UNIVERSITY · PI Laura J. Bierut, Patricia A Cavazos-Rehg · 2017 to 2026
$4.2M
Training in the Genetics and Molecular Biology of Mental DisordersT32MH014677 · NIMH · WASHINGTON UNIVERSITY · PI RICE, JOHN P. · 1985 to 2020
$3.6M
Nicotine Dependence to Smoking Cessation: Sequencing Common and Rare VariantsR01DA036583 · NIDA · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2014 to 2017
$3.0M
Mechanisms of behavior change in a genetics-informed smoking cessation interventionR34DA052928 · NIDA · WASHINGTON UNIVERSITY · PI RAMSEY, ALEX TAYLOR · 2021 to 2023
$709k
NCATS NIH HHS UL1 TR002345NCATS NIH HHS UL1TR002345NCI NIH HHS P30 CA091842NCI NIH HHS P30CA091842NIDA NIH HHS K12 DA041449NIDA NIH HHS K12DA041449NIDA NIH HHS R01 DA036583NIDA NIH HHS R01DA036583NIDA NIH HHS R34 DA052928NIDA NIH HHS T32 DA015035NIDA NIH HHS T32DA015035NIH HHS 5T32MH014677NIMH NIH HHS T32 MH014677
6 · The paper itself

Abstract

backgroundThe use of genetically-informed personalized risk information for behavioral disorders, namely smoking and smoking-related behaviors, is a promising yet understudied area. The Genetics and Smoking Risk Profile, or RiskProfile, leverages genetic and environmental information to communicate one's risk for smoking-related diseases. Although prior studies have examined attitudes toward genetic results, little research has investigated these perceptions through a lens of in-vivo testing; that is, user-centered design feedback in response to personalized genetic results being returned contemporaneously. This qualitative study engaged current smokers in usability testing of the RiskProfile within the context of concurrently receiving this personalized, genetically-informed smoking cessation intervention.

methodsEighty-nine participants who were current smokers responded to open-ended interview questions on perceptions of smoking-related genetic information and the content and format of the RiskProfile intervention that they had received moments before. Data were analyzed via the conventional content analysis approach in which themes were allowed to emerge throughout the analysis.

resultsParticipants were able to reference and offer design input on specific elements of the RiskProfile. Overall, current smokers perceived the RiskProfile to have high potential utility. Constructive feedback that current smokers offered about the tool centered around suggested improvements to optimize its usability and technical content.

conclusionsThe detailed and constructive feedback from participants highlights that in-vivo feedback offers a useful design approach that addresses concerns of rigor and relevance when returning genetic results. This unique method demonstrated perceived utility and constructive design feedback for the RiskProfile among current smokers and can play an important role in optimizing the design and implementation of personalized genetic risk interventions moving forward.

Indexed as

SmokersSmokingAdultAgedFeedbackFemaleHumansMaleMiddle AgedSmoking CessationYoung AdultCessationGeneticsImplementationSmoking

Identifiers

PMID34039360
PMCPMC8152342
OpenAlexW3164601888

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.