Evidence map›Paper›PMID 34041015›Full record

ArticleFrontiers in oncology2021

Synergistic Effect of Statins and Abiraterone Acetate on the Growth Inhibition of Neuroblastoma

Zengchun Hu, Chuandong Cheng, Yue Wang, Tianrui Chen, Junhong Tu, Chaoshi Niu, Rong Xing, Yang Wang, Yinghui Xu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. MYCN in Neuroblastoma: "Old Wine into New Wineskins".Diseases (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Zengchun HuDalian Medical University, Dalian, China.
Chuandong ChengAnhui Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Yue WangDalian Medical University, Dalian, China.
Tianrui ChenDepartment of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Junhong TuDalian Medical University, Dalian, China.
Chaoshi NiuAnhui Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Rong XingDalian Medical University, Dalian, China.
Yang WangDalian Medical University, Dalian, China.
Yinghui XuDepartment of Neurosurgery, 1st Affiliated Hospital of Dalian Medical University, Dalian, China.
Dalian Medical University · CNUniversity of Science and Technology of China · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroblastoma is the most common extracranial neuroendocrine tumor in childhood. Although many studies have tried to find effective treatments, there are still numerous limitations in current clinical targeted therapy. So, it is important to find new therapeutic targets and strategies from a new perspective. Our previous study reported that the androgen receptor (AR) promotes the growth of neuroblastoma

Indexed as

abiraterone acetateandrogen receptorneuroblastomaSREBP cleavage activating proteinstatinsynergistic effect

Identifiers

PMID34041015
PMCPMC8141582
OpenAlexW3163305088

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.