ArticleClinical and experimental pediatrics2021
Update on infantile hemangioma.
Article in Clinical and experimental pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 74 citations in OpenAlex.
- Refractory Ulcerated Infantile Hemangioma Successfully Treated With Bleomycin Sclerotherapy: A Case Report.The American journal of case reports · 2026Article
- Imaging characteristics of parotid gland juvenile capillary hemangioma: A Retrospective analysis of 35 pathologically confirmed cases.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- MULTIPLE INFANTILE HEPATIC HAEMANGIOMA WITH KASABACH-MERRITT SYNDROME PRESENTING WITH RAISED INTRABDOMINAL PRESSURE AND TREATED WITH PROPRANOLOL: A CASE REPORT.Annals of Ibadan postgraduate medicine · 2026Article
- The emerging role of non-coding RNAs in the pathogenesis of infantile hemangioma.Cancer cell international · 2025Review
- Imaging Evaluation and Management of Breast Symptoms in the Pediatric Population.Journal of breast imaging · 2025Review
- Cutis Marmorata Telangiectatica Congenita: Case Series and Literature Review.Diagnostics (Basel, Switzerland) · 2025Article
- Congenital and Neonatal Skin Disorders: Histopathological Diagnosis and Syndromic Associations.Cureus · 2025Review
- Advancing infantile hemangioma diagnosis by integrating temperature, color, and texture.Journal of biomedical optics · 2025Article
- Effects of Notch signaling on proliferation, angiogenesis, and adipogenesis of hemangioma-derived stem cells.European journal of histochemistry : EJH · 2025Article
- A Review of Soft Tissue and Nerve Masses in the Pediatric Hand: Pathology, Diagnosis, and Management Strategies.Cureus · 2025Review
- Recent Advances in Propranolol Hydrochloride Formulations for the Treatment of Infantile Hemangiomas.Drug design, development and therapy · 2025Review
- Case report: Lobular capillary hemangioma of the right main bronchus: a rare case with calcified and cystic lymph nodes.Frontiers in medicine · 2025Article
- A rare complication of infantile hemangioma: Kasabach-Merritt phenomenon.Journal of surgical case reports · 2024Article
- Cryocarboxy Surgery: A New Armamentarium in the Treatment of Infantile Hemangiomas of the Lips.Journal of maxillofacial and oral surgery · 2024Article
- Congenital Disseminated Pyogenic Granuloma: A Case With Numerous Mucocutaneous and Visceral Lesions.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2024Article
- Article
- New Insights into Cervicofacial Vascular Anomalies.Journal of clinical medicine · 2024Review
- Cardiac Evaluation before and after Oral Propranolol Treatment for Infantile Hemangiomas.Journal of clinical medicine · 2024Article
- External Jugular Vein Slow-Flow Venous Malformation Presenting as a Swelling Over the Neck: A Report of a Rare Case.Cureus · 2024Article
- Recent advances in nanomaterial-driven strategies for diagnosis and therapy of vascular anomalies.Journal of nanobiotechnology · 2024Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The International Society for the Study of Vascular Anomalies classifies vascular anomalies into vascular tumors and vascular malformations. Vascular tumors are neoplasms of endothelial cells, among which infantile hemangiomas (IHs) are the most common, occurring in 5%-10% of infants. Glucose transporter-1 protein expression in IHs differs from that of other vascular tumors or vascular malformations. IHs are not present at birth but are usually diagnosed at 1 week to 1 month of age, rapidly proliferate between 1 and 3 months of age, mostly complete proliferation by 5 months of age, and then slowly involute to the adipose or fibrous tissue. Approximately 10% of IH cases require early treatment. The 2019 American Academy of Pediatrics clinical practice guideline for the management of IHs recommends that primary care clinicians frequently monitor infants with IHs, educate the parents about the clinical course, and refer infants with high-risk IH to IH specialists ideally at 1 month of age. High-risk IHs include those with life-threatening complications, functional impairment, ulceration, associated structural anomalies, or disfigurement. In Korea, IHs are usually treated by pediatric hematology-oncologists with the cooperation of pediatric cardiologists, radiologists, dermatologists, and plastic surgeons. Oral propranolol, a nonselective beta-adrenergic antagonist, is the first-line treatment for IHs at a dosage of 2-3 mg/kg/day divided into 2 daily doses maintained for at least 6 months and often continuing until 12 months of age. Topical timolol maleate solution, a topical nonselective beta-blocker, may be used for small superficial type IHs at a dosage of 1-2 drops of 0.5% gel-forming ophthalmic solution applied twice daily. Pulse-dye laser therapy or surgery is useful for the treatment of residual skin changes after IH involution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.