Evidence map›Paper›PMID 34045489›Full record

ArticleScientific reports2021

DHHC21 deficiency attenuates renal dysfunction during septic injury.

Xiaoyuan Yang, Ethan Zheng, Yonggang Ma, Victor Chatterjee, Nuria Villalba, Jerome W Breslin, Ruisheng Liu, Mack H Wu, Sarah Y Yuan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xiaoyuan YangDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, 33612, USA.
Ethan ZhengDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, 33612, USA.
Yonggang MaDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, 33612, USA.
Victor ChatterjeeDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, 33612, USA.
Nuria VillalbaDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, 33612, USA.
Jerome W BreslinDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, 33612, USA.
Ruisheng LiuDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, 33612, USA.
Mack H WuDepartment of Surgery, University of South Florida Morsani College of Medicine, Tampa, Florida, 33612, USA.
Sarah Y YuanDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, 33612, USA. syuan@usf.edu.
University of South Florida · US

Funding

Vascular Barrier Leakage in InflammationR35HL150732 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Sarah Y Yuan · 2020 to 2026
$6.2M
Disintegrin Metalloprotease and Endothelial PermeabilityR01GM097270 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI YUAN, SARAH Y · 2011 to 2020
$2.3M
BLRD VA IK6 BX004210NHLBI NIH HHS R35 HL150732NIGMS NIH HHS R01 GM097270
6 · The paper itself

Abstract

Renal dysfunction is one of the most common complications of septic injury. One critical contributor to septic injury-induced renal dysfunction is renal vascular dysfunction. Protein palmitoylation serves as a novel regulator of vascular function. Here, we examined whether palmitoyl acyltransferase (PAT)-DHHC21 contributes to septic injury-induced renal dysfunction through regulating renal hemodynamics. Multispectral optoacoustic imaging showed that cecal ligation and puncture (CLP)-induced septic injury caused impaired renal excretion, which was improved in DHHC21 functional deficient (Zdhhc21

Indexed as

AcyltransferasesAnimalsCecumKidneyKidney DiseasesLipoylationMiceMice, KnockoutReceptors, Adrenergic, alpha-1SepsisAcyltransferasesReceptors, Adrenergic, alpha-1Zdhhc21 protein, mouse

Identifiers

PMID34045489
PMCPMC8159935
OpenAlexW3135225609

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.