Evidence map›Paper›PMID 34045765›Full record

ArticleNature genetics2021

Non-additive association analysis using proxy phenotypes identifies novel cattle syndromes.

Edwardo G M Reynolds, Catherine Neeley, Thomas J Lopdell, Michael Keehan, Keren Dittmer, Chad S Harland, Christine Couldrey, Thomas J J Johnson, Kathryn Tiplady, Gemma Worth and 10 more

Abstract readLetter
PubMed Publisher
In one paragraph

Article in Nature genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Pooled it
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  6. An Increase in Male Recombination Rate With Age in Dairy Cattle Is Heritable and Polygenic.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026
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  19. Molecular genetic variation of animals and plants under domestication.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 2 countries.

Edwardo G M ReynoldsMassey University, Palmerston North, New Zealand.
Catherine NeeleyLivestock Improvement Corporation, Hamilton, New Zealand.
Thomas J LopdellLivestock Improvement Corporation, Hamilton, New Zealand.
Michael KeehanMassey University, Palmerston North, New Zealand.
Keren DittmerMassey University, Palmerston North, New Zealand.
Chad S HarlandLivestock Improvement Corporation, Hamilton, New Zealand.
Christine CouldreyLivestock Improvement Corporation, Hamilton, New Zealand.
Thomas J J JohnsonLivestock Improvement Corporation, Hamilton, New Zealand.
Kathryn TipladyMassey University, Palmerston North, New Zealand.
Gemma WorthLivestock Improvement Corporation, Hamilton, New Zealand.
Mark WalkerLivestock Improvement Corporation, Hamilton, New Zealand.
Stephen R DavisLivestock Improvement Corporation, Hamilton, New Zealand.
Richard G SherlockLivestock Improvement Corporation, Hamilton, New Zealand.
Katie CarnieLivestock Improvement Corporation, Hamilton, New Zealand.
Bevin L HarrisLivestock Improvement Corporation, Hamilton, New Zealand.
Carole CharlierUniversity of Liège, Liège, Belgium.
Michel GeorgesUniversity of Liège, Liège, Belgium.
Richard J SpelmanLivestock Improvement Corporation, Hamilton, New Zealand.
Dorian J GarrickMassey University, Palmerston North, New Zealand.ORCID http://orcid.org/0000-0001-8640-5372
Mathew D LittlejohnMassey University, Palmerston North, New Zealand. mathew.littlejohn@lic.co.nz.ORCID http://orcid.org/0000-0001-9044-047X
Livestock Improvement Corporation · NZMassey University · NZUniversity of Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mammalian species carry ~100 loss-of-function variants per individual

Indexed as

Loss of Function MutationPhenotypeAllelesAnimalsBiomarkersCattleCattle DiseasesGenome-Wide Association StudyGenotypeInbreedingIncidenceSyndromeBiomarkers

Identifiers

PMID34045765
OpenAlexW3164501648

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.