ArticleFrontiers in behavioral neuroscience2021
Social Experience Regulates Endocannabinoids Modulation of Zebrafish Motor Behaviors.
Article in Frontiers in behavioral neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 9 citations in OpenAlex.
- Socially induced plasticity of the posterior tuberculum and motor behavior in zebrafish (Danio rerio).The Journal of experimental biology · 2024Article
- Socially Mediated Shift in Neural Circuits Activation Regulated by Synergistic Neuromodulatory Signaling.eNeuro · 2023Article
- Article
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6 authors at 2 institutions in 1 country.
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Abstract
Social status-dependent modulation of neural circuits has been investigated extensively in vertebrate and invertebrate systems. However, the effects of social status on neuromodulatory systems that drive motor activity are poorly understood. Zebrafish form a stable social relationship that consists of socially dominant and subordinate animals. The locomotor behavior patterns differ according to their social ranks. The sensitivity of the Mauthner startle escape response in subordinates increases compared to dominants while dominants increase their swimming frequency compared to subordinates. Here, we investigated the role of the endocannabinoid system (ECS) in mediating these differences in motor activities. We show that brain gene expression of key ECS protein pathways are socially regulated. Diacylglycerol lipase (DAGL) expression significantly increased in dominants and significantly decreased in subordinates relative to controls. Moreover, brain gene expression of the cannabinoid 1 receptor (CB
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