Evidence map›Paper›PMID 34046191›Full record

ArticleFuture science OA2021

MicroRNAs miR-4535 and miR-1915-5p in amniotic fluid as predictive biomarkers for chorioamnionitis.

Chihiro Kiyoshima, Naoto Shirasu, Daichi Urushiyama, Satoshi Fukagawa, Toyofumi Hirakawa, Kenichi Yoshikawa, Daisuke Izuchi, Kohei Miyata, Masamitsu Kurakazu, Fusanori Yotsumoto and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future science OA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 2 countries.

Chihiro KiyoshimaDepartment of Obstetrics & Gynecology, Fukuoka University, Fukuoka, Japan.ORCID https://orcid.org/0000-0002-1395-3471
Naoto ShirasuDepartment of Biochemistry, Fukuoka University, Fukuoka, Japan.
Daichi UrushiyamaDepartment of Obstetrics & Gynecology, Fukuoka University, Fukuoka, Japan.
Satoshi FukagawaDepartment of Obstetrics & Gynecology, Fukuoka University, Fukuoka, Japan.
Toyofumi HirakawaDepartment of Obstetrics & Gynecology, Fukuoka University, Fukuoka, Japan.
Kenichi YoshikawaDepartment of Obstetrics & Gynecology, Fukuoka University, Fukuoka, Japan.
Daisuke IzuchiDepartment of Obstetrics & Gynecology, Fukuoka University, Fukuoka, Japan.
Kohei MiyataDepartment of Obstetrics & Gynecology, Fukuoka University, Fukuoka, Japan.
Masamitsu KurakazuDepartment of Obstetrics & Gynecology, Fukuoka University, Fukuoka, Japan.
Fusanori YotsumotoDepartment of Obstetrics & Gynecology, Fukuoka University, Fukuoka, Japan.ORCID https://orcid.org/0000-0001-9411-476X
Kenji HiromatsuDepartment of Microbiology & Immunology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Makoto NomiyamaDepartment of Obstetrics & Gynecology, National Hospital Organization Saga National Hospital, Saga, Japan.
Ohta EijiCenter for Maternal, Foetal & Neonatal Medicine, Fukuoka University Hospital, Fukuoka, Japan.
Shinichi HiroseDepartemnt of Pediatrics, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Yoshitoshi OguraDepartment of Bacteriology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Tetsuya HayashiDepartment of Bacteriology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kenichiro HataDepartment of Maternal-Fetal Biology, National Research Institute for Child Health & Development, Tokyo, Japan.
Kazuki NabeshimaDepartment of Pathology, Fukuoka University School of Medicine & Hospital, Fukuoka, Japan.
Shin'ichiro YasunagaDepartment of Biochemistry, Fukuoka University, Fukuoka, Japan.
Shingo MiyamotoDepartment of Obstetrics & Gynecology, Fukuoka University, Fukuoka, Japan.ORCID https://orcid.org/0000-0002-2782-4240
Fukuoka University · JPFukuoka University Hospital · JPKyushu University · JPNational Center For Child Health and Development · JPNational Hospital Organization · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study was performed to investigate the clinical significance of miR-4535 and miR-1915-5p in severe chorioamnionitis. MATERIALS &

methodsAmniotic fluid samples from 37 patients with severe chorioamnionitis were subjected to miRNA array analysis and ddPCR™. Diagnostic values were assessed using the receiver operating characteristic curve. The patients were separated into three groups according to Blanc's criteria.

resultsThe expression of miR-4535 and miR-1915-5p was significantly correlated with the copy number of 16S rDNA, had extremely high diagnostic accuracy for severe chorioamnionitis, and was linked to maternal and fetal inflammation.

conclusionmiR-4535 and miR-1915-5p serve as promising biomarkers for the diagnosis of severe chorioamnionitis.

Indexed as

16S ribosomal DNAamniotic fluidchorioamnionitisddPCRmiR-1915-5pmiR-4353next-generation sequencing

Identifiers

PMID34046191
PMCPMC8147753
OpenAlexW3130364916

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.