ArticleCurrent biology : CB2021
Natural genetic variation drives microbiome selection in the Caenorhabditis elegans gut.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 92 citations in OpenAlex.
- From diversity to dominance: how salt and CO₂ shape LAB-dominated ecosystems in vegetable fermentations.Microbiology spectrum · 2026Article
- Natural commensal microbes induce internal hatching inMicrobiology spectrum · 2026Article
- Environmental microbial extracts for longitudinal studies of gut microbiome assembly and maintenance.bioRxiv : the preprint server for biology · 2026Article
- Caenorhabditis elegans populations shape their microbial environment.NPJ biofilms and microbiomes · 2026Article
- The bacteria of a fig community.Microbiology spectrum · 2026Article
- The future of Forkhead box O transcription factors.The Biochemical journal · 2026Review
- Host Oxidative Response Capacity Determines Longevity Outcomes of Microbial Interventions.Aging cell · 2026Article
- Pseudomonadota bridge cross-trophic interactions to suppress plant pathogens.The ISME journal · 2026Article
- Cobamide-producing microbes as a model for understanding general nutritional interdependencies in soil food webs.Nature communications · 2026Article
- Caenorhabditis elegans as an experimental model for resilience-boosting microbiota interventions in nonmodel ectotherms.FEMS microbiology reviews · 2026Review
- Defining Microbiome Impact on Host Physiology During Spaceflight Using Caenorhabditis elegans.Methods in molecular biology (Clifton, N.J.) · 2026Article
- A novel, fig-associated microbe promotes reproductive success via variable life history mechanisms inbioRxiv : the preprint server for biology · 2025Article
- A microbial community that alters mitochondrial morphology and age-related motor function iniScience · 2025Article
- Caenorhabditis elegans microbiome members have combinatorial effects on host survival and fitness.Scientific reports · 2025Article
- Machine learning predicts lifespan and suggests underlying causes of death in aging C. elegans.Communications biology · 2025Article
- Gut microbiota mitigate the reproductive toxicity of silver nanoparticles through thiamine-derived metabolites.Nature communications · 2025Article
- Master of Puppets: How Microbiota Drive the Nematoda Ecology and Evolution?Ecology and evolution · 2025Review
- The Interaction Between the Nematode Caenorhabditis elegans and Its Coexisting Fungal Microbiome Member Barnettozyma californica.Environmental microbiology reports · 2025Article
- Dynamics of gut colonization by commensal and pathogenic bacteria that attach to the intestinal epithelium.NPJ biofilms and microbiomes · 2025Article
- Identification of intestinal mediators ofmBio · 2025Article
Corrections and comments
- Commented on by
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Host genetic landscapes can shape microbiome assembly in the animal gut by contributing to the establishment of distinct physiological environments. However, the genetic determinants contributing to the stability and variation of these microbiome types remain largely undefined. Here, we use the free-living nematode Caenorhabditis elegans to identify natural genetic variation among wild strains of C. elegans that drives assembly of distinct microbiomes. To achieve this, we first established a diverse model microbiome that represents the strain-level phylogenetic diversity naturally encountered by C. elegans in the wild. Using this community, we show that C. elegans utilizes immune, xenobiotic, and metabolic signaling pathways to favor the assembly of different microbiome types. Variations in these pathways were associated with enrichment for specific commensals, including the Alphaproteobacteria Ochrobactrum. Using RNAi and mutant strains, we showed that host selection for Ochrobactrum is mediated specifically by host insulin signaling pathways. Ochrobactrum recruitment is blunted in the absence of DAF-2/IGFR and modulated by the competitive action of insulin signaling transcription factors DAF-16/FOXO and PQM-1/SALL2. Further, the ability of C. elegans to enrich for Ochrobactrum as adults is correlated with faster animal growth rates and larger body size at the end of development. These results highlight a new role for the highly conserved insulin signaling pathways in the regulation of gut microbiome composition in C. elegans.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.