Evidence map›Paper›PMID 34049092›Full record

Observational studyInternational journal of hygiene and environmental health2021

COVID-19: Hotspot hospital?- seroprevalence of SARS-CoV-2 antibodies in hospital employees in a secondary care hospital network in Germany: Intermediate results of a prospective surveillance study.

Anke Hildebrandt, Oktay Hökelekli, Lutz Uflacker, Henrik Rudolf, Sören G Gatermann

Open access · hybridAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in International journal of hygiene and environmental health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Seroprevalence of SARS-CoV-2 in hospital workers in the southern region of Minas Gerais state in Brazil: An analysis of the pre-vaccine period.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Anke HildebrandtSt. Vincenz Hospital Datteln, Department of Internal Medicine I, Germany; Institute of Medical Microbiology, University Hospital Münster, Germany. Electronic address: a.hildebrandt@vincenz-datteln.de.
Oktay HökelekliSt. Vincenz Hospital Datteln, Department of Internal Medicine I, Germany.
Lutz UflackerSt. Vincenz Hospital Datteln, Department of Internal Medicine I, Germany.
Henrik RudolfDepartment of Medical Informatics, Biometry and Epidemiology, Ruhr University Bochum, Germany.
Sören G GatermannNational Reference Centre for Multidrug-resistant Gram-negative Bacteria, Ruhr University Bochum, Germany.
St. Vincenz-Krankenhaus Limburg · DERuhr University Bochum · DEUniversity Hospital Münster · DEZimmer Biomet (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe objective of the ongoing study was to investigate how SARS-CoV-2 infection spread within two hospitals in North Rhine-Westphalia, Germany by testing the employees working in high-risk, intermediate-risk and low-risk-areas for the presence of SARS-CoV-2 IgG antibodies. Presented intermediate results evaluate the first infection period until the end of September 2020.

methodsThe study "COVID-19: Hotspot hospital?- Seroprevalence of SARS-CoV-2 antibodies in hospital employees in a secondary care hospital network in Germany " is a prospective, single centre observational cohort study conducted at the St. Vincenz Hospital Datteln with 316 beds. The presented data include one other hospital: St. Laurentius Stift Waltrop, Germany with 172 beds.

resultsBetween June 2020 and September 2020 we analyzed serum samples of 907 employees which represents 62.1% of all employees. Thirteen employees (1.4%), respectively 13/696 healthcare workers (HCWs) (1.9%) had detectable SARS-CoV-2 IgG antibodies. Among them, 4 (30.8%) were aware of COVID-19 exposure, and 5 (38.5%) reported clinical symptoms. HCWs working in high-risk areas had a seroprevalence rate of 1.6% (1/64), HCWs working in intermediate-risk area 1.7% (11/632) and 0.5% employees (1/211) in low-risk areas with no contact to patients were seropositive.

conclusionEven if we treated COVID-19 positive patients, we found no clear evidence that infection was transmitted to HCWs in contact to these patients. As knowledge about SARS-CoV-2 transmission evolves, the concept of infection prevention must be continuously reviewed and adapted as needed to keep hospitals a safe place.

Indexed as

AdolescentAdultAntibodies, ViralCOVID-19Disease HotspotFemaleGermanyHealth PersonnelHumansImmunoglobulin GLongitudinal StudiesMaleProspective StudiesRisk FactorsSARS-CoV-2Secondary Care CentersAntibodies, ViralImmunoglobulin GAntibodiesCoronavirusCOVID-19Healthcare workersSARS-CoV-2

Identifiers

PMID34049092
PMCPMC8135189
OpenAlexW3160756415

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.