Evidence map›Paper›PMID 34049396›Full record

Trial reportThe Journal of nutrition2021

Higher Carbohydrate Amount and Lower Glycemic Index Increase Hunger, Diet Satisfaction, and Heartburn in Overweight and Obese Adults in the OmniCarb Randomized Clinical Trial.

Yingfei Wu, Stephen P Juraschek, Jiun-Ruey Hu, Noel T Mueller, Lawrence J Appel, Cheryl A M Anderson, Edgar R Miller

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00608049 (Optimal Macronutrient Intake - Carbohydrate), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00608049 nacompletednot on this map

Optimal Macronutrient Intake - Carbohydrate

TypeinterventionalSponsorBrigham and Women's HospitalRan2008 to 2011Enrolled189ConditionsOverweight, Cardiovascular DiseasesArmsHigh carbohydrate and low glycemic index (GI) diet, Low carbohydrate and low GI diet, High carbohydrate and high GI diet, Low carbohydrate and high GI diet
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. [Effect of body mass index on efficacy of the repositioning procedure for horizontal canal benign paroxysmal positional vertigo].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Yingfei WuDepartment of Medicine, New York University Langone Health, New York, NY, USA.
Stephen P JuraschekDepartment of Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA.
Jiun-Ruey HuDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Noel T MuellerWelch Center for Epidemiology, Prevention, and Clinical Research, Johns Hopkins University School of Public Health, Baltimore, MD, USA.
Lawrence J AppelWelch Center for Epidemiology, Prevention, and Clinical Research, Johns Hopkins University School of Public Health, Baltimore, MD, USA.
Cheryl A M AndersonHerbert Wertheim School of Public Health, University of California San Diego, San Diego, CA, USA.
Edgar R MillerWelch Center for Epidemiology, Prevention, and Clinical Research, Johns Hopkins University School of Public Health, Baltimore, MD, USA.
Johns Hopkins University · USBeth Israel Deaconess Medical Center · USNYU Langone Health · USUniversity of California, San Diego · USVanderbilt University Medical Center · US

Funding

Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
Carbohydrate: Amount and Type Affecting Risk for CVD and DiabetesR01HL084568 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SACKS, FRANK M · 2007 to 2011
$10.2M
Vitamin D, Subclinical Cardiovascular Disease, and Orthostatic Hypotension in Older AdultsK23HL135273 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI JURASCHEK, STEPHEN P · 2017 to 2021
$1.1M
NHLBI NIH HHS K23 HL135273NHLBI NIH HHS R01 HL084568NIDDK NIH HHS P30 DK072488
6 · The paper itself

Abstract

backgroundThe Dietary Approaches to Stop Hypertension (DASH) diet, a high-carbohydrate diet, is highly recommended based on its cardiovascular risk benefits, yet adherence remains persistently low. How subjective impressions of this diet contribute to adherence has not been thoroughly explored. The OmniCarb trial, which compared DASH-style diets varying in glycemic index (GI) and carbohydrate amount, surveyed subjective impressions of such diets.

objectivesWe examined the effects of GI and carbohydrate amount on qualitative aspects of diet acceptability through secondary outcomes in the OmniCarb trial.

methodsOmniCarb was a randomized, crossover trial of 4 DASH-style diets varying by GI (≥65 compared with ≤45) and carbohydrate amount (40% compared with 58% kcal) in overweight or obese (BMI ≥25 kg/m2) adults (n = 163). Participants consumed each diet in random order over 5-wk periods, separated by 2-wk washouts. At baseline and the end of each feeding period, participants rated hunger, diet satisfaction, and gastrointestinal symptoms (diarrhea/loose stools, constipation, bloating, nausea, and heartburn).

resultsParticipant mean age was 52 y, with 52% women, 51% non-Hispanic black, and 56% obese (BMI ≥30). Compared with baseline, all intervention diets decreased heartburn, increased diarrhea/loose stools, and increased bloating, but did not significantly affect constipation or nausea. Compared with lower carbohydrate diets, higher carbohydrate diets increased hunger (RR: 1.16; 95% CI: 1.04, 1.30), increased diet satisfaction (RR: 1.10; 95% CI: 1.01, 1.20), and increased heartburn (RR: 1.49; 95% CI: 1.09, 2.04). Compared with lower GI diets, higher GI diets did not affect hunger (RR: 0.92; 95% CI: 0.83, 1.02), decreased diet satisfaction (RR: 0.83; 95% CI: 0.75, 0.92), and did not affect heartburn (RR: 0.89; 95% CI: 0.70, 1.13). There were no between-diet differences for diarrhea/loose stools, constipation, bloating, and nausea.

conclusionsAlthough a higher carbohydrate amount in DASH-style diets can increase diet satisfaction, it can also decrease satiety and increase heartburn in adults with overweight or obesity.This trial is registered at clinicaltrials.gov as NCT00608049.

Indexed as

Glycemic IndexOverweightAdultDietDietary CarbohydratesFemaleHeartburnHumansHungerMaleMiddle AgedObesityPersonal SatisfactionDietary Carbohydratescarbohydratesdiet satisfactiongastrointestinal symptomsglycemic indexhungerOmniCarb

Identifiers

PMID34049396
PMCPMC8349117
OpenAlexW3165471987

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.