Evidence map›Paper›PMID 34056099›Full record

ArticleACS central science2021

Bacterial Peptidoglycan Fragments Differentially Regulate Innate Immune Signaling.

Klare L Bersch, Kristen E DeMeester, Rachid Zagani, Shuyuan Chen, Kimberly A Wodzanowski, Shuzhen Liu, Siavash Mashayekh, Hans-Christian Reinecker, Catherine L Grimes

Open access · diamondAbstract read
In one paragraph

Article in ACS central science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
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  4. Article
  5. ACS infectious diseases · 2026
    Article
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  7. Article
  8. Article
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  20. Evaluation and Comparison ofBiochemistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Klare L BerschDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Kristen E DeMeesterDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Rachid ZaganiDepartment of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.
Shuyuan ChenDepartment of Medicine, Division of Digestive and Liver Diseases, and Department of Immunology, University of Texas Southwestern Medical Center, 5959 Harry Hines Boulevard, Dallas, Texas 75390, United States.
Kimberly A WodzanowskiDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Shuzhen LiuDepartment of Medicine, Division of Digestive and Liver Diseases, and Department of Immunology, University of Texas Southwestern Medical Center, 5959 Harry Hines Boulevard, Dallas, Texas 75390, United States.
Siavash MashayekhDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Hans-Christian ReineckerDepartment of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.
Catherine L GrimesDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0002-0586-2879
University of Delaware · USHarvard University · USThe University of Texas Southwestern Medical Center · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
Innate Immune Defense Mechanisms in the IntestineR01AI113333 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI REINECKER, HANS-CHRISTIAN · 2014 to 2025
$5.7M
Chemistry-Biology Interface Predoctoral Training Grant 2024-2029T32GM133395 · NIGMS · UNIVERSITY OF DELAWARE · PI Catherine Leimkuhler Grimes · 2019 to 2026
$3.7M
Peptidoglycan Fragment Library to Investigate Innate Immune ResponsesR01GM138599 · NIGMS · UNIVERSITY OF DELAWARE · PI GRIMES, CATHERINE LEIMKUHLER, REINECKER, HANS-CHRISTIAN · 2020 to 2023
$2.0M
NIAID NIH HHS R01 AI113333NIDDK NIH HHS P30 DK043351NIGMS NIH HHS R01 GM138599NIGMS NIH HHS T32 GM133395
6 · The paper itself

Abstract

The human innate immune system responds to both pathogen and commensal bacteria at the molecular level using bacterial peptidoglycan (PG) recognition elements. Traditionally, synthetic and commercially accessible PG monosaccharide units known as muramyl dipeptide (MDP) and

Identifiers

PMID34056099
PMCPMC8155477
OpenAlexW3139465266

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.