Evidence mapPaperPMID 34056928Full record

ArticleAmerican journal of physiology. Renal physiology2021

Local and downstream actions of proximal tubule angiotensin II signaling on Na

Jonathan W Nelson, Alicia A McDonough, Zhidan Xiang, Donna L Ralph, Joshua A Robertson, Jorge F Giani, Kenneth E Bernstein, Susan B Gurley

Open access · hybridAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jonathan W NelsonDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.ORCID 0000-0003-1456-9399
Alicia A McDonoughDepartment of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0002-0459-469X
Zhidan XiangWake Forest University, Winston-Salem, North Carolina.
Donna L RalphDepartment of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, California.
Joshua A RobertsonDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
Jorge F GianiDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.ORCID 0000-0003-0481-6595
Kenneth E BernsteinDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Susan B GurleyDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
Oregon Health & Science University · USCedars-Sinai Medical Center · USUniversity of Southern California · USWake Forest University · US

Funding

USC RESEARCH CENTER FOR LIVER DISEASES: PILOT PROGRAMSP30DK048522 · UNIVERSITY OF SOUTHERN CALIFORNIA · 1995 to 2005
$5.4M
Renal electrolyte handling in females vs. males over life cycleR01DK083785 · UNIVERSITY OF SOUTHERN CALIFORNIA · 2025 to 2025
$534k
Actions of ACE2 along with Nephron to Regulate Blood PressureR01DK098382 · UNIVERSITY OF SOUTHERN CALIFORNIA · 2025 to 2025
$534k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01 AI143599NHLBI NIH HHS P01 HL129941NHLBI NIH HHS R01 HL142672NIDDK NIH HHS K01 DK121737NIDDK NIH HHS P30 DK048522NIDDK NIH HHS R01 DK083785NIDDK NIH HHS R01 DK098382NIDDK NIH HHS R56 DK123780
6 · The paper itself

Abstract

The renal nephron consists of a series of distinct cell types that function in concert to maintain fluid and electrolyte balance and blood pressure. The renin-angiotensin system (RAS) is central to Na

Indexed as

Angiotensin IIAnimalsKidneyMembrane Transport ProteinsNatriuresisNephronsSodium-Hydrogen ExchangersSolute Carrier Family 12, Member 3Angiotensin IIMembrane Transport ProteinsSodium-Hydrogen ExchangersSolute Carrier Family 12, Member 3angiotensin receptornephronproximal tubuletransporters

Identifiers

PMID34056928
PMCPMC8321806
OpenAlexW3165813920

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.