ArticleDigestive diseases and sciences2022
Microscopic Colitis Patients Possess a Perturbed and Inflammatory Gut Microbiota.
Article in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Microbiome Composition in Microscopic Colitis: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Exploring the etiology of colitis: insights from gut microbiota research.Gut microbes · 2025Review
- Dissecting Microscopic Colitis Immunopathophysiology: Insights From Basic Research.United European gastroenterology journal · 2025Review
- The adoption of a westernized gut microbiome in Indian Immigrants and Indo-Canadians is associated with dietary acculturation.NPJ biofilms and microbiomes · 2025Article
- Dysbiosis of Gut Microbiota in Microscopic Colitis: Diagnostic and Therapeutic Implications.Diagnostics (Basel, Switzerland) · 2025Review
- Association of distinct microbial and metabolic signatures with microscopic colitis.Nature communications · 2025Article
- Rome Foundation Working Team Report on overlap in disorders of gut-brain interaction.Nature reviews. Gastroenterology & hepatology · 2025Review
- Special Issue: Gut Microbiota in Disease and Health 2.0.International journal of molecular sciences · 2024Article
- Proton pump inhibitor-induced gut dysbiosis and immunomodulation: current knowledge and potential restoration by probiotics.Pharmacological reports : PR · 2023Review
- Microscopic Colitis: Pathogenesis and Diagnosis.Journal of clinical medicine · 2023Review
- Gut microbiota and synbiotic foods: Unveiling the relationship in COVID-19 perspective.Food science & nutrition · 2023Review
- Article
- Obesity is associated with decreased risk of microscopic colitis in women.World journal of gastroenterology · 2022Article
- Insights into the underlying mechanisms and clinical management of microscopic colitis in relation to other gastrointestinal disorders.Gastroenterology report · 2022Review
- Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C.The Journal of experimental medicine · 2021Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicroscopic colitis (MC), an inflammatory disease of the colon, is characterized by chronic non-bloody diarrhea with characteristic inflammation and for some, collagen deposits in mucosal biopsies. The etiology of MC is unclear, although previous findings implicate luminal factors and thus the gut microbiome. However, the relationships between fecal microbiota and MC are relatively unexplored.
methodsStool microbiota of MC (n = 15) and healthy controls (HC; n = 21) were assessed by 16S rRNA V4 amplicon sequencing and analysis performed in QIIME. Gut microbiota functions were predicted using Piphillin and inflammatory potential assessed using an in vitro HT29 colonocyte cell assay.
resultsMC patient fecal microbiota were less diverse (Faiths index; p < 0.01) and compositionally distinct (PERMANOVA, weighted UniFrac, R
conclusionMC gut microbiota are distinct from HC and characterized by lower bacterial diversity and Prevotella enrichment and distinct predicted functional pathways. Limited in vitro experiments indicate that compared with cell-free products from healthy fecal microbiota, MC microbiota induce distinct responses when co-cultured with epithelial cells, implicating microbiota perturbation in MC-associated mucosal dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.