ArticleLiver international : official journal of the International Association for the Study of the Liver2021
Using MR elastography to assess portal hypertension and response to beta-blockers in patients with cirrhosis.
Article in Liver international : official journal of the International Association for the Study of the Liver, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Monitoring Liver and Spleen Stiffness Changes May Predict Clinical Response to Non-selective B-Blockers in Portal Hypertension: A Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2026Pooled it
- On the History of Hepatic Vein Catheterization.Liver international : official journal of the International Association for the Study of the Liver · 2026Review
- Quantitative MRI to Assess Portal Pressure in Patients With Liver Disease: Validation at 3 T.NMR in biomedicine · 2026Article
- Recent Advances in the Diagnosis and Management of Clinically Significant Portal Hypertension in Liver Cirrhosis: A Clinical Review.Biomedicines · 2026Review
- Preliminary quantitative assessment of liver and spleen MR imaging and elastography in clinically significant portal hypertension.Scientific reports · 2026Article
- The pathophysiological role of portal hypertension in metabolic dysfunction-associated steatotic liver disease.Hepatology communications · 2025Review
- Diagnosis of Portal Hypertension.Diagnostics (Basel, Switzerland) · 2025Review
- Use of Noninvasive Tests to Assess Clinically Significant Portal Hypertension and Response to Beta-Blockers.Gastro hep advances · 2025Review
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- Article
- Superiority of spleen stiffness on two-dimensional magnetic resonance elastography over liver stiffness and serum tests in assessing portal hypertension in chronic liver disease.Quantitative imaging in medicine and surgery · 2024Article
- Recent Advances in the Pathogenesis and Clinical Evaluation of Portal Hypertension in Chronic Liver Disease.Gut and liver · 2024Review
- Spleen stiffness determined by spleen-dedicated device accurately predicted esophageal varices in cirrhosis patients.Therapeutic advances in chronic disease · 2023Article
- Application of Ultrasound Elastography in Assessing Portal Hypertension.Diagnostics (Basel, Switzerland) · 2022Review
- Bibliometric-analysis visualization and review of non-invasive methods for monitoring and managing the portal hypertension.Frontiers in medicine · 2022Review
- Update on the Evaluation and Management of Portal Hypertension.Gastroenterology & hepatology · 2021Article
- Understanding clinically significant portal hypertension: an in-depth look at pathogenesis, diagnosis and treatment.Annals of gastroenterologyReview
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundMR elastography can determine organ-related stiffness, which reflects the degree of fibrosis. Liver stiffness increases in cirrhosis, and stiffness increases further post-prandially due to increased portal blood in-flow. Non-selective beta-blockers (NSBB) reduce the portal venous inflow, but their effect on liver and spleen stiffness are disputed.
aimsTo assess whether MR elastography of the liver or spleen reflects the severity of cirrhosis, whether treatment with NSBB changes liver and spleen stiffness and whether changes in stiffness can predict the effect of NSBB on portal pressure.
methodsFifty-two patients with cirrhosis underwent liver vein catheterization and two-dimensional (2D) MR elastography on separate days. Thirty-six of the patients had a hepatic venous pressure gradient (HVPG) of ≥12 mmHg and were tested prior to, and after, intravenous infusion of NSBB using HVPG measurement and MR elastography.
resultsHVPG showed a strong, positive, linear relationship with liver stiffness (r
conclusionsTwo-dimensional MR elastographic estimation of liver or spleen stiffness reflects the degree of portal hypertension in patients with liver cirrhosis, but changes in stiffness after NSBB do not predict the effect on HVPG.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.