Evidence map›Paper›PMID 34060972›Full record

SynthesisAnnals of medicine2021

Genetic variant in

Lin-Lin Zhang, Xiao-Xiao Wu, Xu-Fan Wang, Dong-Sheng Di, Qian Huang, Rui-Shan Liu, Zong-Wen Shuai, Dong-Qing Ye, Rui-Xue Leng

Open access · goldAbstract readMeta-Analysis
In one paragraph

Synthesis in Annals of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. miR-146a mimic therapy protects against platelet-mediated thrombosis.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. MiRNA-146a-A Key Player in Immunity and Diseases.International journal of molecular sciences · 2023
    Review
  9. Automated clustering reveals CD4Frontiers in immunology · 2023
    Article
  10. Article
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lin-Lin ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, PR China.
Xiao-Xiao WuDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, PR China.
Xu-Fan WangDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, PR China.
Dong-Sheng DiDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, PR China.
Qian HuangDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, PR China.
Rui-Shan LiuDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, PR China.
Zong-Wen ShuaiDepartment of Rheumatology and Immunology, the First Affiliated Hospital of Anhui Medical University, Hefei, PR China.
Dong-Qing YeDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, PR China.
Rui-Xue LengDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, PR China.
Anhui Medical University · CNFirst Affiliated Hospital of Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigated the association between single nucleotide polymorphisms (SNPs) in

methodsWe systemically extracted the genetic data of

resultsThe extracted genetic association data from three previous GWASs showed that the allele T of functional SNP rs2431697 increased RA susceptibility. The significant association for the SNP was also found in the Chinese replication cohort (OR = 1.24, 95% CI = 1.06-1.46,

conclusionsIn summary, this study supports that genetic variant in

Indexed as

Arthritis, RheumatoidMicroRNAsCase-Control StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansPolymorphism, Single NucleotideTumor Necrosis Factor-alphaMicroRNAsTumor Necrosis Factor-alphacytokineMiR-146arheumatoid arthritissingle nucleotide polymorphismssusceptibility

Identifiers

PMID34060972
PMCPMC8172213
OpenAlexW3165257403

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.