Evidence map›Paper›PMID 34061024›Full record

ArticleeLife2021

Pore mutation N617D in the skeletal muscle DHPR blocks Ca

Anamika Dayal, Monica L Fernández-Quintero, Klaus R Liedl, Manfred Grabner

Open access · goldAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Advances in CaChannels (Austin, Tex.) · 2023
    Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Anamika DayalDepartment of Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0001-8075-8812
Monica L Fernández-QuinteroInstitute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.ORCID 0000-0002-6811-6283
Klaus R LiedlInstitute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.ORCID 0000-0002-0985-2299
Manfred GrabnerDepartment of Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0002-5196-4024
Innsbruck Medical University · ATUniversität Innsbruck · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle excitation-contraction (EC) coupling roots in Ca

Indexed as

Calcium SignalingPoint MutationAnimalsCalciumCalcium Channels, L-TypeCells, CulturedExcitation Contraction CouplingMice, TransgenicMolecular Dynamics SimulationMuscle, SkeletalPermeabilityProtein BindingProtein ConformationStructure-Activity RelationshipCACNA1S protein, mouseCalciumCalcium Channels, L-Typeca2+ permeationca2+ selectivitymolecular biophysicsmousenc dhprnon-conducting dhprpore binding affinityskeletal muscle excitation-contraction couplingstructural biologyvoltage-gated ca2+ channel

Identifiers

PMID34061024
PMCPMC8184209
OpenAlexW3165518883

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.