Evidence map›Paper›PMID 34063993›Full record

ReviewInternational journal of environmental research and public health2021

Role of Stress-Survival Pathways and Transcriptomic Alterations in Progression of Colorectal Cancer: A Health Disparities Perspective.

Urbashi Basnet, Abhijeet R Patil, Aditi Kulkarni, Sourav Roy

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Recent advancements and limitations of intestinal organoids for clinical applications.Progress in biomedical engineering (Bristol, England) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Urbashi BasnetDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968, USA.
Abhijeet R PatilComputational Science Program, University of Texas at El Paso, El Paso, TX 79968, USA.ORCID 0000-0003-1444-1555
Aditi KulkarniDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968, USA.
Sourav RoyDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968, USA.ORCID 0000-0002-0359-994X
The University of Texas at El Paso · US

Funding

NIH HHS 5U54MD007592 PILOT Project
6 · The paper itself

Abstract

Every year, more than a million individuals are diagnosed with colorectal cancer (CRC) across the world. Certain lifestyle and genetic factors are known to drive the high incidence and mortality rates in some groups of individuals. The presence of enormous amounts of reactive oxygen species is implicated for the on-set and carcinogenesis, and oxidant scavengers are thought to be important in CRC therapy. In this review, we focus on the ethnicity-based CRC disparities in the U.S., the negative effects of oxidative stress and apoptosis, and gene regulation in CRC carcinogenesis. We also highlight the use of antioxidants for CRC treatment, along with screening for certain regulatory genetic elements and oxidative stress indicators as potential biomarkers to determine the CRC risk and progression.

Indexed as

Colorectal NeoplasmsTranscriptomeCarcinogenesisHumansOxidative StressReactive Oxygen SpeciesReactive Oxygen Speciesantioxidantsapoptosisbiomarkersgene regulationmicroRNAsoxidative stress

Identifiers

PMID34063993
PMCPMC8196775
OpenAlexW3164252938

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.