Evidence mapPaperPMID 34064301Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Zinc Oxide Nanoparticles Protected with Terpenoids as a Substance in Redox Imbalance Normalization in Burns.

Nina Melnikova, Alyona Balakireva, Dmitry Orekhov, Denis Kamorin, Natalia Didenko, Darina Malygina, Alexander Knyazev, Denis Novopoltsev, Anna Solovyeva

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. The Use of Metallic Nanoparticles in Wound Healing: New Perspectives.International journal of molecular sciences · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Nina MelnikovaFaculty of Chemistry, Lobachevsky University, 23/5 Gagarin Av., 603950 Nizhny Novgorod, Russia.ORCID 0000-0003-1335-1048
Alyona BalakirevaCentral Research Laboratory, Privolzhsky Research Medical University, 10/1 Minin Sq., 603950 Nizhny Novgorod, Russia.
Dmitry OrekhovEngineering-Technology Faculty, Nizhny Novgorod State Technical University n.a. R.E. Alekseev, 24 Minin St., 603950 Nizhny Novgorod, Russia.ORCID 0000-0002-2820-4705
Denis KamorinEngineering-Technology Faculty, Nizhny Novgorod State Technical University n.a. R.E. Alekseev, 24 Minin St., 603950 Nizhny Novgorod, Russia.
Natalia DidenkoCentral Research Laboratory, Privolzhsky Research Medical University, 10/1 Minin Sq., 603950 Nizhny Novgorod, Russia.ORCID 0000-0001-6653-1267
Darina MalyginaDepartment of Pharmaceutical Chemistry, Privolzhsky Research Medical University, 10/1 Minin Sq., 603950 Nizhny Novgorod, Russia.ORCID 0000-0002-6962-8547
Alexander KnyazevFaculty of Chemistry, Lobachevsky University, 23/5 Gagarin Av., 603950 Nizhny Novgorod, Russia.
Denis NovopoltsevCentral Research Laboratory, Privolzhsky Research Medical University, 10/1 Minin Sq., 603950 Nizhny Novgorod, Russia.ORCID 0000-0002-8074-7985
Anna SolovyevaCentral Research Laboratory, Privolzhsky Research Medical University, 10/1 Minin Sq., 603950 Nizhny Novgorod, Russia.ORCID 0000-0001-6890-4530
Privolzhsky Research Medical University · RUNizhny Novgorod State Technical University · RUN. I. Lobachevsky State University of Nizhny Novgorod · RU

Funding

Council on grants of the President of the Russian Federation MK-4120.2021.1.3Ministry of Science and Higher Education of the Russian Federation 0729-2020-0039
6 · The paper itself

Abstract

Preliminary protection of zinc oxide nanoparticles (ZnO NPs) with terpenoids such as betulin, its derivatives, and essential oils components has been proposed to produce gel-like oleophilic and hydrophilic formulations. We studied the properties of gel-like dispersions of ZnO NPs with immobilized terpenoids and their effects on the activity of LDH, GR, G6PDH, restoration of redox balance of co-enzyme pairs NAD+/NADH and NADP+/NADPH, as well as the activity of SOD, catalase, AlDH in erythrocytes in the treatment of burns in rats. Hysteresis loops on the rheograms of studied dispersions characterize their thixotropic properties. ZnO NPs with betulin diphosphate in the water-ethanol medium lead to a 20-fold increase in the hydrodynamic radius at pH 7.3 compared to the initial ZnO NPs, and facilitate the formation of Zn

Indexed as

betulinbetulin diphosphatehydro- and oleo-dispersions of zinc oxide nanoparticleslavender oilredox balance of NAD+/NADH and NADP+/NADPHterpenoidsthyme oil

Identifiers

PMID34064301
PMCPMC8224349
OpenAlexW3162173685

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.