Evidence map›Paper›PMID 34064804›Full record

ArticleCells2021

Physiological Fitness and the Pathophysiology of Chronic Lymphocytic Leukemia (CLL).

Andrea Sitlinger, Michael A Deal, Erwin Garcia, Dana K Thompson, Tiffany Stewart, Grace A MacDonald, Nicolas Devos, David Corcoran, Janet S Staats, Jennifer Enzor and 4 more

Abstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Andrea SitlingerHematologic Malignancies and Cellular Therapy, Duke University School of Medicine, Durham, NC 27705, USA.ORCID 0000-0002-2231-5527
Michael A DealDivision of Medical Oncology, Duke University School of Medicine, Durham, NC 27710, USA.
Erwin GarciaLaboratory Corporation of America Holdings, Morrisville, NC 27560, USA.ORCID 0000-0002-2956-2715
Dana K ThompsonVA Medical Center, Division of Hematology, Duke University School of Medicine, Durham, NC 27710, USA.
Tiffany StewartVA Medical Center, Division of Hematology, Duke University School of Medicine, Durham, NC 27710, USA.
Grace A MacDonaldDivision of Medical Oncology, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0002-7947-3630
Nicolas DevosDuke Center for Genomic and Computational Biology, Duke University, Durham, NC 27705, USA.
David CorcoranDuke Center for Genomic and Computational Biology, Duke University, Durham, NC 27705, USA.
Janet S StaatsDivision of Surgical Sciences, Duke University School of Medicine, Durham, NC 27707, USA.
Jennifer EnzorDivision of Surgical Sciences, Duke University School of Medicine, Durham, NC 27707, USA.
Kent J WeinholdDivision of Surgical Sciences, Duke University School of Medicine, Durham, NC 27707, USA.
Danielle M BranderHematologic Malignancies and Cellular Therapy, Duke University School of Medicine, Durham, NC 27705, USA.
J Brice WeinbergVA Medical Center, Division of Hematology, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0003-4052-5576
David B BartlettDivision of Medical Oncology, Duke University School of Medicine, Durham, NC 27710, USA.

Funding

Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Virginia B Kraus · 2006 to 2026
$24.6M
TRANSFUSION MEDICINE AND RELATED AREAST32HL007057 · NHLBI · DUKE UNIVERSITY · PI Gowthami M Arepally · 1985 to 2026
$10.6M
Center for AIDS Research, Duke University P30 AI64518NHLBI NIH HHS T32 HL007057NIA NIH HHS P30 AG028716
6 · The paper itself

Abstract

Chronic lymphocytic leukemia (CLL) is associated with physical dysfunction and low overall fitness that predicts poor survival following the commencement of treatment. However, it remains unknown whether higher fitness provides antioncogenic effects. We identified ten fit (CLL-FIT) and ten less fit (CLL-UNFIT) treatment-naïve CLL patients from 144 patients who completed a set of physical fitness and performance tests. Patient plasma was used to determine its effects on an

Indexed as

Cell SurvivalInflammationPhenotypeAgedAged, 80 and overB-LymphocytesCell Line, TumorExerciseExosomesFemaleHumansKiller Cells, NaturalLeukemia, Lymphocytic, Chronic, B-CellLipoproteinsMagnetic Resonance SpectroscopyMaleLipoproteinsMicroRNAsagingNGS exosomal miRNANK cell phenotypeNMR lipoprotein and inflammationphysical fitness

Identifiers

PMID34064804
PMCPMC8151485

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.