Evidence map›Paper›PMID 34064873›Full record

ReviewToxins2021

Jiří Bejček, Michal Jurášek, Vojtěch Spiwok, Silvie Rimpelová

Abstract readReview
In one paragraph

Review in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Black Oat (Current pharmaceutical design · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Molecules (Basel, Switzerland) · 2025
    Article
  7. Article
  8. Cellular and molecular aspects of drug resistance in cancers.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024
    Review
  9. Digoxin and its NaBioorganic & medicinal chemistry · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. The NaFrontiers in endocrinology · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiří BejčekDepartment of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 5, Prague 6, Czech Republic.
Michal JurášekDepartment of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 3, Prague 6, Czech Republic.ORCID 0000-0002-5069-9716
Vojtěch SpiwokDepartment of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 5, Prague 6, Czech Republic.ORCID 0000-0001-8108-2033
Silvie RimpelováDepartment of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 5, Prague 6, Czech Republic.ORCID 0000-0002-3008-1396

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac glycosides (CGs), toxins well-known for numerous human and cattle poisoning, are natural compounds, the biosynthesis of which occurs in various plants and animals as a self-protective mechanism to prevent grazing and predation. Interestingly, some insect species can take advantage of the CG's toxicity and by absorbing them, they are also protected from predation. The mechanism of action of CG's toxicity is inhibition of Na

Indexed as

Molecular Targeted TherapyAnimalsAntineoplastic AgentsCardiac GlycosidesCattleDigitoxinDigoxinHumansNeoplasmsOuabainSodium-Potassium-Exchanging ATPaseAntineoplastic AgentsCardiac GlycosidesDigitoxinDigoxinOuabainSodium-Potassium-Exchanging ATPaseantiviral potentialcancer treatmentcardenolidesdigitoxindigoxindrug repositioningimmunogenic cell deathNa+/K+ ATPasesecondary plant metabolitestoxins

Identifiers

PMID34064873
PMCPMC8151307

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.