Evidence map›Paper›PMID 34065016›Full record

ReviewJournal of fungi (Basel, Switzerland)2021

The Known Unknowns of the Immune Response to

Rebecca A Ward, George R Thompson, Alexandra-Chloé Villani, Bo Li, Michael K Mansour, Marcel Wuethrich, Jenny M Tam, Bruce S Klein, Jatin M Vyas

Open access · goldAbstract readReview
In one paragraph

Review in Journal of fungi (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Type-2 immune skewing in patients with disseminated coccidioidomycosis.medRxiv : the preprint server for health sciences · 2025
    Article
  5. Early immune response toMicrobiology spectrum · 2025
    Article
  6. Article
  7. From soil to clinic: current advances in understandingMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  8. Article
  9. The Host Response to Coccidioidomycosis.Journal of fungi (Basel, Switzerland) · 2024
    Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Rebecca A WardDepartment of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0001-6752-5600
George R ThompsonDepartment of Internal Medicine, University of California Davis Medical Center, Sacramento, CA 96817, USA.ORCID 0000-0001-8518-5750
Alexandra-Chloé VillaniCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Bo LiCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Michael K MansourDepartment of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.
Marcel WuethrichDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA.
Jenny M TamHarvard Medical School, Boston, MA 02115, USA.
Bruce S KleinDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA.
Jatin M VyasDepartment of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-9985-9565
Harvard University · USBroad Institute · USUniversity of Wisconsin–Madison · USMassachusetts General Hospital · USUniversity of California Davis Medical Center · US

Funding

PROTECTIVE IMMUNE RESPONSES TO BLASTOMYCES DERMATITIDISR01AI040996 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN, WUETHRICH, MARCEL · 1997 to 2023
$10.4M
Molecular Pathogenesis of BlastomycosisR37AI035681 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BRUCE Steven KLEIN · 2004 to 2026
$6.9M
Control of Type I Interferon Production in Response to Candida albicansR01AI150181 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Jatin M Vyas · 2020 to 2026
$5.4M
Regulation of vaccine-induced anti-fungal Th17 cellsR01AI093553 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI WUETHRICH, MARCEL · 2011 to 2020
$4.5M
MOLECULAR PATHOGENESIS OF BLASTOMYCOSISR01AI035681 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 1995 to 2019
$3.9M
The Functional Role of the Tetraspanin CD82/Kai1 in Fungal Innate ImmunityR01AI136529 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2018 to 2022
$2.7M
Lung epithelial cell regulation of immunity to inhaled fungiR01AI130411 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2018 to 2021
$2.0M
The role of spleen tyrosine kinase (syk) in neutrophil responses to pathogenic fungi.R01AI132638 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MANSOUR, MICHAEL K · 2018 to 2021
$1.6M
NIAID NIH HHS R01 AI040996NIAID NIH HHS R01 AI130411NIAID NIH HHS R01 AI132638NIAID NIH HHS R01 AI136529NIAID NIH HHS R01 AI150181NIAID NIH HHS R37 AI035681NIH HHS R01AI035681NIH HHS R01AI040996NIH HHS R01AI093553NIH HHS R01AI130411NIH HHS R01AI132638NIH HHS R01AI136529NIH HHS R01AI150181
6 · The paper itself

Abstract

Coccidioidomycosis, otherwise known as Valley Fever, is caused by the dimorphic fungi

Indexed as

adaptive immunitycoccidioidomycosisinnate immunityrespiratory epitheliumsingle-cell RNA sequencingspatial transcriptomicsvaccine strategies

Identifiers

PMID34065016
PMCPMC8151481
OpenAlexW3162552175

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.