Evidence map›Paper›PMID 34065421›Full record

ArticleInternational journal of molecular sciences2021

Rapamycin Alternatively Modifies Mitochondrial Dynamics in Dendritic Cells to Reduce Kidney Ischemic Reperfusion Injury.

Maria Namwanje, Bijay Bisunke, Thomas V Rousselle, Gene G Lamanilao, Venkatadri S Sunder, Elizabeth C Patterson, Canan Kuscu, Cem Kuscu, Daniel Maluf, Manjari Kiran and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. [Role of SPP1 in acute kidney injury induced by renal ischemia-reperfusion in rats].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
  7. Article
  8. Review
  9. Effects of three types of freshIranian journal of basic medical sciences · 2023
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Maria NamwanjeDepartment of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Bijay BisunkeDepartment of Genetics, Genomics, and Informatics, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Thomas V RousselleDepartment of Surgery, Surgical Sciences Division, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Gene G LamanilaoTransplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Venkatadri S SunderDepartment of Systems and Computational Biology, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India.
Elizabeth C PattersonTransplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Canan KuscuTransplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Cem KuscuTransplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Daniel MalufDivision of Transplant Surgery, University of Maryland Medical Center, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Manjari KiranDepartment of Systems and Computational Biology, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India.ORCID 0000-0003-0153-7072
Valeria MasDepartment of Surgery, Surgical Sciences Division, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
James D EasonTransplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Amandeep BajwaTransplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0003-0517-8871
University of Tennessee Health Science Center · USUniversity of Maryland, Baltimore · USUniversity of Hyderabad · IN

Funding

Assessment of Donor Quality for Improving Kidney Transplant OutcomesR01DK109581 · NIDDK · UNIVERSITY OF VIRGINIA · PI Kellie J. Archer, Valeria Raquel Mas · 2017 to 2026
$4.0M
Dissecting the role of dynamic epigenome prompting pathways leading to kidney allograft fibrosisR01DK122682 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MAS, VALERIA RAQUEL · 2019 to 2023
$3.6M
Mitochondrial Therapy for Kidney InjuryR01DK117183 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI BAJWA, AMANDEEP · 2018 to 2022
$1.7M
NIDDK NIH HHS R01 DK109581NIDDK NIH HHS R01 DK117183NIDDK NIH HHS R01 DK122682NIH HHS R01DK117183
6 · The paper itself

Abstract

Dendritic cells (DCs) are unique immune cells that can link innate and adaptive immune responses and Immunometabolism greatly impacts their phenotype. Rapamycin is a macrolide compound that has immunosuppressant functions and is used to prevent graft loss in kidney transplantation. The current study evaluated the therapeutic potential of

Indexed as

Acute Kidney InjuryAdoptive TransferAnimalsCytokinesDendritic CellsHEK293 CellsHumansInflammationIschemiaKidneyMaleMiceMice, Inbred BALB CMice, Inbred C57BLMitochondriaMitochondrial DynamicsCytokinesSirolimusacute kidney injurydendritic cellischemic reperfusion injurymitochondriarapamycin

Identifiers

PMID34065421
PMCPMC8160749
OpenAlexW3160670157

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.